Role of environmental toxicants on neurodegenerative disorders

M Nabi, N Tabassum - Frontiers in toxicology, 2022 - frontiersin.org
Neurodegeneration leads to the loss of structural and functioning components of neurons
over time. Various studies have related neurodegeneration to a number of degenerative …

[HTML][HTML] Cognitive impairment induced by lead exposure during lifespan: mechanisms of lead neurotoxicity

DR Ortega, DFG Esquivel, TB Ayala, B Pineda… - Toxics, 2021 - ncbi.nlm.nih.gov
Lead (Pb) is considered a strong environmental toxin with human health repercussions. Due
to its widespread use and the number of people potentially exposed to different sources of …

Kynurenic acid in neurodegenerative disorders—Unique neuroprotection or double‐edged sword?

A Ostapiuk, EM Urbanska - CNS neuroscience & therapeutics, 2022 - Wiley Online Library
Aims The family of kynurenine pathway (KP) metabolites includes compounds produced
along two arms of the path and acting in clearly opposite ways. The equilibrium between …

Minocycline, a classic antibiotic, exerts psychotropic effects by normalizing microglial neuroinflammation-evoked tryptophan-kynurenine pathway dysregulation in …

D Cheng, ZS Qin, Y Zheng, JY Xie, SS Liang… - Brain, Behavior, and …, 2023 - Elsevier
The dysregulation of tryptophan-kynurenine pathway (TKP) is extensively involved in the
pathophysiology of Alzheimer's disease, depression, and neurodegenerative disorders …

Kynurenine pathway metabolites as biomarkers in Alzheimer's disease

Y Liang, S Xie, Y He, M Xu, X Qiao, Y Zhu… - Disease …, 2022 - Wiley Online Library
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that deteriorates
cognitive function. Patients with AD generally exhibit neuroinflammation, elevated beta …

Cognitive Impairment Induced by lead exposure during Lifespan: mechanisms of lead neurotoxicity

D Ramírez Ortega, DF González Esquivel… - Toxics, 2021 - mdpi.com
Lead (Pb) is considered a strong environmental toxin with human health repercussions. Due
to its widespread use and the number of people potentially exposed to different sources of …

Addiction and the kynurenine pathway: A new dancing couple?

N Morales-Puerto, P Gimenez-Gomez… - Pharmacology & …, 2021 - Elsevier
Drug use poses a serious threat to health systems throughout the world and the number of
consumers rises relentlessly every year. The kynurenine pathway, main pathway of …

Neuropathogenesis-on-chips for neurodegenerative diseases

S Amartumur, H Nguyen, T Huynh, TS Kim… - Nature …, 2024 - nature.com
Developing diagnostics and treatments for neurodegenerative diseases (NDs) is
challenging due to multifactorial pathogenesis that progresses gradually. Advanced in vitro …

Association Study Between Kynurenine 3-Monooxygenase (KMO) Gene and Parkinson's Disease Patients

HWS Babu, A Elangovan, M Iyer, L Kirola… - Molecular …, 2024 - Springer
The influence of various risk factors such as aging, intricate cellular molecular processes,
and lifestyle factors like smoking, alcohol consumption, caffeine intake, and occupational …

Kynurenine and oxidative stress in children having learning disorder with and without attention deficit hyperactivity disorder: possible role and involvement

A Kilany, NH Nashaat, HM Zeidan, AF Hashish… - BMC neurology, 2022 - Springer
Background The etiological and pathophysiological factors of learning disorder (LD) and
attention deficit hyperactivity disorder (ADHD) are currently not well understood. These …