Type IV pili: dynamics, biophysics and functional consequences

L Craig, KT Forest, B Maier - Nature reviews microbiology, 2019 - nature.com
The surfaces of many bacteria are decorated with long, exquisitely thin appendages called
type IV pili (T4P), dynamic filaments that are rapidly polymerized and depolymerized from a …

Structure and function of minor pilins of type IV pili

T Jacobsen, B Bardiaux, O Francetic… - Medical microbiology …, 2020 - Springer
Type IV pili are versatile and highly flexible fibers formed on the surface of many Gram-
negative and Gram-positive bacteria. Virulence and infection rate of several pathogenic …

Motility and adhesion through type IV pili in Gram-positive bacteria

KH Piepenbrink, EJ Sundberg - Biochemical Society …, 2016 - portlandpress.com
Type IV pili are hair-like bacterial surface appendages that play a role in diverse processes
such as cellular adhesion, colonization, twitching motility, biofilm formation, and horizontal …

DNA uptake by type IV filaments

KH Piepenbrink - Frontiers in Molecular Biosciences, 2019 - frontiersin.org
Bacterial uptake of DNA through type IV filaments is an essential component of natural
competence in numerous gram-positive and gram-negative species. Recent advances in the …

The minor pilin PilV provides a conserved adhesion site throughout the antigenically variable meningococcal type IV pilus

JP Barnier, J Meyer, S Kolappan… - Proceedings of the …, 2021 - National Acad Sciences
Neisseria meningitidis utilizes type IV pili (T4P) to adhere to and colonize host endothelial
cells, a process at the heart of meningococcal invasive diseases leading to meningitis and …

The Vibrio cholerae Minor Pilin TcpB Initiates Assembly and Retraction of the Toxin-Coregulated Pilus

D Ng, T Harn, T Altindal, S Kolappan, JM Marles… - PLoS …, 2016 - journals.plos.org
Type IV pilus (T4P) systems are complex molecular machines that polymerize major pilin
proteins into thin filaments displayed on bacterial surfaces. Pilus functions require rapid …

Exploiting pilus-mediated bacteria-host interactions for health benefits

V Sharma, I von Ossowski, V Krishnan - Molecular Aspects of Medicine, 2021 - Elsevier
Surface pili (or fimbriae) are an important but conspicuous adaptation of several genera and
species of Gram-negative and Gram-positive bacteria. These long and non-flagellar multi …

Architecture of the Vibrio cholerae toxin-coregulated pilus machine revealed by electron cryotomography

YW Chang, A Kjær, DR Ortega, G Kovacikova… - Nature …, 2017 - nature.com
Abstract Type IV pili (T4P) are filamentous appendages found on many Bacteria and
Archaea. They are helical fibres of pilin proteins assembled by a multi-component …

PilB from Streptococcus sanguinis is a bimodular type IV pilin with a direct role in adhesion

C Raynaud, D Sheppard, JL Berry… - Proceedings of the …, 2021 - National Acad Sciences
Type IV pili (T4P) are functionally versatile filamentous nanomachines, nearly ubiquitous in
prokaryotes. They are predominantly polymers of one major pilin but also contain minor …

Structure and properties of a natural competence-associated pilin suggest a unique pilus tip-associated DNA receptor

MZ Salleh, V Karuppiah, M Snee, A Thistlethwaite… - MBio, 2019 - Am Soc Microbiol
Natural competence is the term used to describe the uptake of “naked” extracellular DNA by
bacteria; it plays a significant role in horizontal genetic exchange. It is associated with type …