Abstract Interferon-α (IFN-α) has proven to be a clinically effective antiviral and
antineoplastic therapeutic drug for more than 16 years. During this time, evidence from in …

CD8+ T-cells are a critical component of the cellular immune response and they play an
important role in the control of viral infection. During HIV infection, CD8+ T-cells are able to …

Identification of T-cell subsets that are infected in vivo is essential to understanding the
pathogenesis of human immunodeficiency virus (HIV) disease; however, this goal has been …

Deuterated glucose labeling was used to measure the in vivo turnover of T lymphocytes. A
realistic T cell kinetic model, with populations of resting and activated T cells, was fitted to d …

Great progress has been made with respect to our understanding of the
immunopathogenesis of AIDS and the infectious agent, HIV, that causes the disease. HIV, a …

The accessory protein Nef of human immunodeficiency virus (HIV) is a primary determinant
of viral pathogenesis. Nef is abundantly expressed during infection and reroutes a variety of …

The feline immunodeficiency virus (FIV) model provides a system to study lentivirus
transmission, virus kinetics, pathogenesis, host responses, and immune dysfunction in a …

Dysregulation of the bone marrow niche resulting from the direct and indirect effects of HIV
infection contributes to haematological abnormalities observed in HIV patients. The bone …

Recognition of cell-surface receptors and co-receptors is a crucial molecular event towards
the establishment of HIV infection. HIV exists as several variants that differentially recognize …

Costimulation of purified CD8+ T lymphocytes induces de novo expression of CD4,
suggesting a previously unrecognized function for this molecule in the immune response …