Chondrocyte hypertrophy in osteoarthritis: mechanistic studies and models for the identification of new therapeutic strategies

S Chawla, A Mainardi, N Majumder, L Dönges… - Cells, 2022 - mdpi.com
Articular cartilage shows limited self-healing ability owing to its low cellularity and
avascularity. Untreated cartilage defects display an increased propensity to degenerate …

[HTML][HTML] Recent development in multizonal scaffolds for osteochondral regeneration

L Yu, S Cavelier, B Hannon, M Wei - Bioactive Materials, 2023 - Elsevier
Osteochondral (OC) repair is an extremely challenging topic due to the complex biphasic
structure and poor intrinsic regenerative capability of natural osteochondral tissue. In …

Physical, mechanical, and biological properties of fibrin scaffolds for cartilage repair

JA Rojas-Murillo, MA Simental-Mendía… - International Journal of …, 2022 - mdpi.com
Articular cartilage is a highly organized tissue that provides remarkable load-bearing and
low friction properties, allowing for smooth movement of diarthrodial joints; however, due to …

Within or without you? A perspective comparing in situ and ex situ tissue engineering strategies for articular cartilage repair

CD O'Connell, S Duchi, C Onofrillo… - Advanced …, 2022 - Wiley Online Library
Human articular cartilage has a poor ability to self‐repair, meaning small injuries often lead
to osteoarthritis, a painful and debilitating condition which is a major contributor to the global …

Human chondrocytes, metabolism of articular cartilage, and strategies for application to tissue engineering

D Bačenková, M Trebuňová, J Demeterová… - International Journal of …, 2023 - mdpi.com
Hyaline cartilage, which is characterized by the absence of vascularization and innervation,
has minimal self-repair potential in case of damage and defect formation in the chondral …

Cartilage 3D bioprinting for rhinoplasty using adipose‐derived stem cells as seed cells: Review and recent advances

C Zhang, G Wang, H Lin, Y Shang, N Liu… - Cell …, 2023 - Wiley Online Library
Nasal deformities due to various causes affect the aesthetics and use of the nose, in which
case rhinoplasty is necessary. However, the lack of cartilage for grafting has been a major …

Transforming Osteoarthritis Treatment: Embracing Hydrogel Microspheres

J Chen, X Zhou, Y Li, T Liu, W Ding, F He… - ACS Materials …, 2024 - ACS Publications
Osteoarthritis (OA) is a chronic condition characterized by degeneration of the articular
cartilage and subsequent bone hyperplasia. With the increasing prevalence driven by …

Roles of cartilage-resident stem/progenitor cells in cartilage physiology, development, repair and osteoarthritis

W Xu, W Wang, D Liu, D Liao - Cells, 2022 - mdpi.com
Osteoarthritis (OA) is a degenerative disease that causes irreversible destruction of articular
cartilage for which there is no effective treatment at present. Although articular cartilage …

Robotic in situ bioprinting for cartilage tissue engineering

Y Wang, RF Pereira, C Peach, B Huang… - … Journal of Extreme …, 2023 - iopscience.iop.org
Articular cartilage damage caused by trauma or degenerative pathologies such as
osteoarthritis can result in significant pain, mobility issues, and disability. Current surgical …

Nasal cartilage tissue engineering materials based on 3D bioprinting: Seed cells and dECM

W Jia, X Yang, Z Liu, L Sun, Z Shen, M Li, H Zhang… - Applied Materials …, 2024 - Elsevier
The nasal cartilage plays a crucial role in supporting the nose and facilitating respiration,
however has a limited regenerative capabilities once damaged. Nasal cartilage tissue …