The angiotensin-converting enzyme 2 (ACE2) is the host functional receptor for the new
virus SARS-CoV-2 causing Coronavirus Disease 2019. ACE2 is expressed in 72 different …

Glioma cells overexpress different peptide receptors that are useful for research, diagnosis,
management, and treatment of the disease. Oncogenic peptides favor the proliferation …

Glioblastoma (GBM) is an aggressive malignant primary brain tumor with limited therapeutic
options. We show that the angiotensin II (AngII) type 2 receptor (AT2R) is a therapeutic target …

Glioma, the most common primary malignancy in the brain, has high recurrence and lethality
rates, and thus, elucidation of the molecular mechanisms of this incurable disease is …

Pancreatic cancer is among the most lethal malignancies with poor prognosis and patients
become chemoresistant to current therapies, supporting further investigations to identify new …

The renin-angiotensin system (RAS) regulates physiological functions of the cardiovascular
system, kidneys, and other tissues. Various in vivo and in vitro studies have shown that RAS …

Changes in the endothelium of the cerebral vasculature can contribute to inflammatory,
thrombotic, and malignant disorders. The importance of defining cell-type-specific genes …

Patients with glioblastoma (GB), a highly aggressive brain tumor, have a median survival of
14.6 months following neurosurgical resection and adjuvant chemoradiotherapy. Quiescent …

A perfect microenvironment facilitates the activated circulating tumor cells (CTCs) to spark
the adhesion-invasion-extravasation metastatic cascade in their premetastatic niche …

Classic Hodgkin lymphoma (CHL) is a highly curable disease, even in advanced stages.
Controversy remains over whether bone involvement negatively affects overall and …