Electric barrier-induced voluntary abstinence reduces alcohol seeking in male, but not female, iP rats.

XJ Maddern, AJ Lawrence… - Behavioral Neuroscience, 2024 - psycnet.apa.org
Maintaining abstinence and preventing relapse are key to the successful recovery from
alcohol use disorder. There are two main ways individuals with alcohol use disorder abstain …

Control of goal-directed and inflexible actions by dorsal striatal melanocortin systems, in coordination with the central nucleus of the amygdala

EC Heaton, EH Seo, LM Butkovich, ST Yount… - Progress in …, 2024 - Elsevier
The dorsomedial striatum (DMS) is associated with flexible goal seeking, as opposed to
routinized habits. Whether local mechanisms brake this function, for instance when habits …

A molecularly defined orbitofrontal cortical neuron population controls compulsive-like behavior, but not inflexible choice or habit

ST Yount, S Wang, AT Allen, LP Shapiro… - Progress in …, 2024 - Elsevier
Habits are familiar behaviors triggered by cues, not outcome predictability, and are
insensitive to changes in the environment. They are adaptive under many circumstances but …

Cordycepin buffers anisomycin-induced fear memory deficit by restoring hippocampal BDNF

M Li, L Wang, S Guo, N Huang, H Ai - Biochemical and Biophysical …, 2023 - Elsevier
The process of memory consolidation involves the synthesis of new proteins, and interfering
with protein synthesis through anisomycin can impair memory. Memory deficits due to aging …

Striatal melanocortin-4 receptor control of action flexibility

EC Heaton - 2023 - search.proquest.com
More than half of all individuals in treatment for substance use disorder (SUD) will relapse.
Inflexibility in selecting between familiar, habitual behaviors that have been rewarded in the …