Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders

G Navarro, P Morales, C Rodríguez-Cueto… - Frontiers in …, 2016 - frontiersin.org
Endocannabinoids activate two types of specific G-protein-coupled receptors (GPCRs),
namely cannabinoid CB1 and CB2. Contrary to the psychotropic actions of agonists of CB1 …

Current Applications of Bicelles in NMR Studies of Membrane-Associated Amphiphiles and Proteins,

RS Prosser, F Evanics, JL Kitevski… - Biochemistry, 2006 - ACS Publications
This review covers current trends in studies of membrane amphiphiles and membrane
proteins using both fast tumbling bicelles and magnetically aligned bicelle media for both …

Bicelles as model membranes for solid‐and solution‐state NMR studies of membrane peptides and proteins

I Marcotte, M Auger - Concepts in Magnetic Resonance Part A …, 2005 - Wiley Online Library
Bicelles are an attractive membrane mimetic system because of their planar surface and
lipid composition, which resemble biological membranes. In addition, their orientation and …

When detergent meets bilayer: birth and coming of age of lipid bicelles

UHN Dürr, R Soong, A Ramamoorthy - Progress in nuclear magnetic …, 2013 - Elsevier
► Lipid bicelles have matured to full membership in the club of lipid phases.► Numerous
techniques have elucidated the character traits of bicelles.► Bicelles are exemplary citizens …

Soft nanoparticles (thermo-responsive nanogels and bicelles) with biotechnological applications: from synthesis to simulation through colloidal characterization

J Ramos, A Imaz, J Callejas-Fernández… - Soft Matter, 2011 - pubs.rsc.org
The use of nanotechnology in biotechnological applications has attracted tremendous
attention from researchers. Currently many nanomaterials, such as soft nanoparticles, are …

2012 Division of medicinal chemistry award address. Trekking the cannabinoid road: a personal perspective

A Makriyannis - Journal of medicinal chemistry, 2014 - ACS Publications
My involvement with the field of cannabinoids spans close to 3 decades and covers a major
part of my scientific career. It also reflects the robust progress in this initially largely …

The conformation, location, and dynamic properties of the endocannabinoid ligand anandamide in a membrane bilayer

X Tian, J Guo, F Yao, DP Yang… - Journal of Biological …, 2005 - ASBMB
The endogenous cannabinoid ligand anandamide is biosynthesized from membrane
phospholipid precursors and is believed to reach its sites of action on the CB1 and CB2 …

Behavioral effects of vaporized delta-8 tetrahydrocannabinol, cannabidiol, and mixtures in male rats

DJ Durbin, JM King, DJ Stairs - Cannabis and Cannabinoid …, 2024 - liebertpub.com
Background: The popularity of delta-8 tetrahydrocannabinol (THC) and cannabidiol (CBD)
products has seen a sharp increase in use during recent years. Despite the rise in use of …

How lipophilic cannabinergic ligands reach their receptor sites

A Makriyannis, X Tian, J Guo - Prostaglandins & other lipid mediators, 2005 - Elsevier
It is postulated that lipophilic ligands reach their sites of action on membrane-bound
functional proteins through fast lateral diffusion across the membrane bilayer. We have …

Conformation and location of membrane-bound salinomycin− sodium complex deduced from NMR in isotropic bicelles

N Matsumori, A Morooka, M Murata - Journal of the American …, 2007 - ACS Publications
An ionophore antibiotic salinomycin was studied in a membrane environment consisting of
isotropic bicelles, a better model for biological membranes than micelles, and its …