RNA adopts 3D structures that confer varied functional roles in human biology and
dysfunction in disease. Approaches to therapeutically target RNA structures with small …

RNA is a key regulator of almost every cellular process, and the structures adopted by RNA
molecules are thought to be central to their functions. The recent fast-paced evolution of high …

Recent events have pushed RNA research into the spotlight. Continued discoveries of RNA
with unexpected diverse functions in healthy and diseased cells, such as the role of RNA as …

Over the past decade, RNA sequencing (RNA-seq) has become an indispensable tool for
transcriptome-wide analysis of differential gene expression and differential splicing of …

Beyond transferring genetic information, RNAs are molecules with diverse functions that
include catalyzing biochemical reactions and regulating gene expression. Most of these …

RNAs fold into 3D structures that range from simple helical elements to complex tertiary
structures and quaternary ribonucleoprotein assemblies. The functions of many regulatory …

RNA molecules can fold into intricate shapes that can provide an additional layer of control
of gene expression beyond that of their sequence. In this Review, we discuss the current …

Therapeutic mRNAs and vaccines are being developed for a broad range of human
diseases, including COVID-19. However, their optimization is hindered by mRNA instability …

Messenger RNAs (mRNAs) encode information in both their primary sequence and their
higher order structure. The independent contributions of factors like codon usage and …

Long noncoding RNAs (lncRNAs) have emerged as significant players in almost every level
of gene function and regulation. Thus, characterizing the structures and interactions of …