CRISPR/Cas technology has revolutionized the fields of the genome-and epigenome-
editing by supplying unparalleled control over genomic sequences and expression …

CRISPR/Cas9 genome editing is a promising therapeutic technique, which makes precise
and rapid gene editing technology possible on account of its high sensitivity and efficiency …

Alpha-synuclein SNCA has been implicated in the etiology of Parkinson's disease (PD);
however, the normal function of alpha-synuclein protein and the pathway that mediates its …

The limited biomolecular and functional stability of lentiviral vectors (LVVs) for cell therapy
poses the need for analytical tools that can monitor their titers and activity throughout the …

Epigenetic dysregulation is an important determinant of many pathological conditions and
diseases. Designer molecules that can specifically target endogenous DNA sequences …

Overexpression of SNCA has been implicated in the pathogenesis of synucleinopathies,
particularly Parkinson's disease (PD) and dementia with Lewy bodies (DLB). While PD and …

Currently, there is a lack of effective treatment for Parkinson's disease (PD). In PD patients,
aberrant methylation of SNCA (α-synuclein gene) has been reported and may be a potential …

Lentiviral vectors are an ideal gene-delivery system for large gene-editing tools, such as the
clustered regularly interspaced short palindromic repeat (CRISPR)-Cas9 system, due to …

The most widely used genome editing toolkit is CRISPR (clustered regularly interspaced
short palindromic repeats). It provides the possibility of replacing and modifying DNA and …

Glial cells (astrocytes, oligodendrocytes, and microglia) are emerging as key players in
several physiological and pathological processes of the central nervous system (CNS) …