J Yan, X Wang - Trends in Plant Science, 2023 - cell.com
Some of the biological knowledge obtained from fundamental research will be implemented in applied plant breeding. To bridge basic research and breeding practice, machine learning …
Joint profiling of chromatin accessibility and gene expression in individual cells provides an opportunity to decipher enhancer-driven gene regulatory networks (GRNs). Here we present …
V Venkataramani, Y Yang, MC Schubert, E Reyhan… - Cell, 2022 - cell.com
Glioblastomas are incurable tumors infiltrating the brain. A subpopulation of glioblastoma cells forms a functional and therapy-resistant tumor cell network interconnected by tumor …
AGX Zeng, S Bansal, L Jin, A Mitchell, WC Chen… - Nature medicine, 2022 - nature.com
The treatment landscape of acute myeloid leukemia (AML) is evolving, with promising therapies entering clinical translation, yet patient responses remain heterogeneous, and …
There is a pressing need for allogeneic chimeric antigen receptor (CAR)-immune cell therapies that are safe, effective and affordable. We conducted a phase 1/2 trial of cord …
Mononuclear phagocytes (MNPs) encompass dendritic cells, monocytes, and macrophages (MoMac), which exhibit antimicrobial, homeostatic, and immunoregulatory functions. We …
We present an integrated analysis of the clinical measurements, immune cells, and plasma multi-omics of 139 COVID-19 patients representing all levels of disease severity, from serial …
H Wu, RG Villalobos, X Yao, D Reilly, T Chen… - Cell metabolism, 2022 - cell.com
Diabetic kidney disease (DKD) occurs in∼ 40% of patients with diabetes and causes kidney failure, cardiovascular disease, and premature death. We analyzed the response of a …