Evidence has arisen in recent years suggesting that a tissue renin-angiotensin system
(tRAS) is involved in the progression of various human diseases. This system contains two …

Inflammation is a normal part of the immune response to injury or infection but its
dysregulation promotes the development of inflammatory diseases, which cause …

Atherosclerotic lesions initiate in regions characterized by low shear stress and reduced
activity of endothelial atheroprotective molecules such as nitric oxide, which is the key …

Angiotensin II, an important component of renin angiotensin system, is a potent vasopressor
and its actions are mostly mediated via angiotensin II type 1 receptor (AT 1 R) and role of AT …

LCZ696 blocks both angiotensin receptor type 1 (ATR1) and neprilysin (NEP), which are
intricate in the degradation of natriuretic peptides (NPs) and other endogenous peptides. It …

Homeostasis in the cardiovascular system is maintained by physiological functions of the
Renin Angiotensin Aldosterone System (RAAS). In pathophysiological conditions, over …

To assess the influence of lipid-lowering therapy on coronary plaque volume, and to identify
the LDL and HDL targets for plaque regression to provide a comprehensive overview. The …

Background Conflicting results currently exist on the effects of LDL-C levels and statins
therapy on coronary atherosclerotic plaque, and the target level of LDL-C resulting in the …

Hypertension is a growing global health problem, and is predicted to affect 1.56 billion
people by 2025. Treatment remains suboptimal, with control of blood pressure achieved in …

Background Progression of atherosclerosis is associated with a greater risk for adverse
outcomes. Angiotensin II plays a key role in the pathogenesis and progression of …