Nrf2-mediated anti-inflammatory polarization of macrophages as therapeutic targets for osteoarthritis

L Wang, C He - Frontiers in immunology, 2022 - frontiersin.org
Macrophages are the most abundant immune cells within the synovial joints, and also the
main innate immune effector cells triggering the initial inflammatory responses in the …

Exosomes rewire the cartilage microenvironment in osteoarthritis: from intercellular communication to therapeutic strategies

Y Wu, J Li, Y Zeng, W Pu, X Mu, K Sun… - International journal of …, 2022 - nature.com
Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by cartilage loss
and accounts for a major source of pain and disability worldwide. However, effective …

Reprogramming mitochondrial metabolism in synovial macrophages of early osteoarthritis by a camouflaged meta‐defensome

L Zhang, X Chen, P Cai, H Sun, S Shen… - Advanced …, 2022 - Wiley Online Library
Osteoarthritis (OA) is a low‐grade inflammatory and progressive joint disease, and its
progression is closely associated with an imbalance in M1/M2 synovial macrophages …

Nanomedicines reprogram synovial macrophages by scavenging nitric oxide and silencing CA9 in progressive osteoarthritis

Y Yan, A Lu, Y Dou, Z Zhang, XY Wang… - Advanced …, 2023 - Wiley Online Library
Osteoarthritis (OA) is a progressive joint disease characterized by inflammation and
cartilage destruction, and its progression is closely related to imbalances in the M1/M2 …

Targeting macrophage polarization as a promising therapeutic strategy for the treatment of osteoarthritis

W Wang, Y Chu, P Zhang, Z Liang, Z Fan, X Guo… - International …, 2023 - Elsevier
Osteoarthritis (OA) is a chronic osteoarthropathy characterized by the progressive
degeneration of articular cartilage and synovial inflammation. Early OA clinical treatments …

Regulatory Mechanisms of Prg4 and Gdf5 Expression in Articular Cartilage and Functions in Osteoarthritis

Y Takahata, H Hagino, A Kimura, M Urushizaki… - International Journal of …, 2022 - mdpi.com
Owing to the rapid aging of society, the numbers of patients with joint disease continue to
increase. Accordingly, a large number of patients require appropriate treatment for …

Low-grade inflammation in the pathogenesis of osteoarthritis: Cellular and molecular mechanisms and strategies for future therapeutic intervention

MA Terkawi, T Ebata, S Yokota, D Takahashi, T Endo… - Biomedicines, 2022 - mdpi.com
Osteoarthritis (OA) is a musculoskeletal disease characterized by cartilage degeneration
and stiffness, with chronic pain in the affected joint. It has been proposed that OA …

Overview of first-line and second-line pharmacotherapies for osteoarthritis with special focus on intra-articular treatment

A Nowaczyk, D Szwedowski, I Dallo… - International Journal of …, 2022 - mdpi.com
Osteoarthritis (OA) can be defined as the result of pathological processes of various
etiologies leading to damage to the articular structures. Although the mechanism of …

M2 macrophage polarization: A potential target in pain relief

W Zhao, L Ma, D Deng, T Zhang, L Han, F Xu… - Frontiers in …, 2023 - frontiersin.org
Pain imposes a significant urden on patients, affecting them physically, psychologically, and
economically. Despite numerous studies on the pathogenesis of pain, its clinical …

Dexamethasone liposomes alleviate osteoarthritis in miR-204/-211-deficient mice by repolarizing synovial macrophages to M2 phenotypes

H Teng, S Chen, K Fan, Q Wang, B Xu… - Molecular …, 2023 - ACS Publications
We undertook this study to investigate the effects and mechanisms of dexamethasone
liposome (Dex-Lips) on alleviating destabilization of the medial meniscus (DMM)-induced …