Generally, changes in the metabolic status of cells under conditions like hypoxia and
accumulation of lactate can be sensed by various sensing mechanisms, leading to …

Microtubules, complex cytoskeletal structures composed of tubulin proteins in eukaryotic
cells, have garnered recent attention in cardiovascular research. Investigations have …

Cardiomyocyte apoptosis and cardiac fibrosis are the leading causes of mortality in patients
with ischemic heart disease. As such, these processes represent potential therapeutic …

The mechanisms orchestrating recycling of lysosomes through autophagic lysosome
reformation (ALR) is incompletely understood. Previous data show that genetic depletion of …

Hepatic gluconeogenesis is crucial for maintaining blood glucose during starvation, and a
major contributor for hyperglycemia. Cellular redox state is related to mitochondrial biology …

GCN5L1 regulates mitochondrial protein acetylation, cellular bioenergetics, reactive oxygen
species (ROS) generation, and organelle positioning in a number of diverse cell types …

GCN5L1 regulates protein acetylation and mitochondrial energy metabolism in diverse cell
types. In the heart, loss of GCN5L1 sensitizes the myocardium to injury from exposure to …

BACKGROUND: Nearly half of adults have hypertension, a major risk factor for
cardiovascular disease. Mitochondrial hyperacetylation is linked to hypertension, but the …

Background and Aims The regenerative capacity of the liver plays a protective role against
hepatotoxins and impaired regeneration exacerbates liver dysfunction in nonalcoholic fatty …

The phagocytosis and destruction of pathogens in lysosomes constitute central elements of
innate immune defense. Here, we show that Brucella, the causative agent of brucellosis, the …