In today's research environment, a wealth of experimental/theoretical structural data is
available and the number of therapeutically relevant macromolecular structures is growing …

Cytosine base editors (CBEs) offer a powerful tool for correcting point mutations, yet their
DNA and RNA off-target activities have caused concerns in biomedical applications. We …

The complexity of cancer and the vast amount of experimental data available have made
computer-aided approaches necessary. Biomolecular modelling techniques are becoming …

In recent years, enterovirus 71 (EV71) has been a cause of numerous outbreaks of hand-
foot-and-mouth disease, with severe neurological complications in the Asia-Pacific region …

Rheumatoid arthritis (RA) is an autoimmune and chronic inflammatory disease that leads to
pannus formation followed by severe joint destruction, characterized by synovial …

The aim of the present study was todeterminecharacteristics of Rheb gene and protein in
Raini Cashmere goat. Comparative analyses of the nucleotide sequences were performed …

Septins are members of the GTPase superfamily, which has been implicated in diverse
cellular functions including cytokinesis and morphogenesis. Septin 12 (SEPT12) is a testis …

Background Template selection and target-template alignment are critical steps for template-
based modeling (TBM) methods. To identify the template for the twilight zone of 15~ 25 …

Abstract Fatty Acid Desaturase 2 (FAD2), a key enzyme in the fatty acid biosynthesis
pathway, is involved in the desaturation and conversion of oleic acid to linoleic acid …

The progress in biological technologies has led to rapid accumulation of microbial genomic
sequences with a vast number of uncharacterized genes. Proteins encoded by these genes …