Preparation of a carboxylated single-walled carbon-nanotube-chitosan functional layer and its application to a molecularly imprinted electrochemical sensor to …

W Yu, Y Tang, Y Sang, W Liu, S Wang, X Wang - Food Chemistry, 2020 - Elsevier
Semicarbazide (SEM) is a protein-bound nitrofurazone metabolite that is detrimental to
human health. Therefore, to ensure food safety, it is necessary to detect SEM in food …

Multi-adductomics: Advancing mass spectrometry techniques for comprehensive exposome characterization

MR Chao, YJ Chang, MS Cooke, CW Hu - TrAC Trends in Analytical …, 2024 - Elsevier
Adductomics, an emerging field within the'omics sciences, focuses on the formation and
prevalence of DNA, RNA, and protein adducts induced by endogenous and exogenous …

A Novel Adductomics Workflow Incorporating FeatureHunter Software: Rapid Detection of Nucleic Acid Modifications for Studying the Exposome

CW Hu, YJ Chang, WH Chang, MS Cooke… - Environmental …, 2023 - ACS Publications
Exposure to the physicochemical agents that interact with nucleic acids (NA) may lead to
modification of DNA and RNA (ie, NA modifications), which have been associated with …

Anthracyclines react with apurinic/apyrimidinic sites in DNA

M Bellamri, JT Terrell, K Brandt, F Gruppi… - ACS chemical …, 2023 - ACS Publications
The combination of doxorubicin (Adriamycin) and cyclophosphamide, referred to as AC
chemotherapy, is commonly used for the clinical treatment of breast and other cancers. Both …

DNA–protein cross-links formed by reacting lysine with apurinic/apyrimidinic sites in DNA and human cells: Quantitative analysis by liquid chromatography–tandem …

W Chan, L Jin - Analytical Chemistry, 2021 - ACS Publications
Accumulating evidence suggests that DNA lesion-induced DNA–protein cross-links (DPCs)
interrupt normal DNA metabolic processes, such as transcription, replication, and repair …

In vitro DNA/RNA Adductomics to Confirm DNA Damage Caused by Benzo[a]pyrene in the Hep G2 Cell Line

T Takeshita, RA Kanaly - Frontiers in Chemistry, 2019 - frontiersin.org
In the development of new chemical substances, genetic toxicity evaluations are a high
priority for safety risk management. Evaluation of the possibility of compound carcinogenicity …

Plant uptake and metabolism of nitrofuran antibiotics in spring onion grown in nitrofuran-contaminated soil

Y Wang, KKJ Chan, W Chan - Journal of Agricultural and Food …, 2017 - ACS Publications
Environmental pollution caused by the discharge of mutagenic and carcinogenic nitrofurans
to the aquatic and soil environment is an emerging public health concern because of the …

RNA adduction derived from electrophilic species in vitro and in vivo

M Zhou, DO Wang, W Li, J Zheng - Chemico-Biological Interactions, 2022 - Elsevier
RNA molecules are essential for cell function by not only serving as genetic materials, but
also providing cells with structural support and catalytic functions. Due to nucleophilicity of …

Quantification of a novel DNA–protein cross-link product formed by reacting apurinic/apyrimidinic sites in DNA with cysteine residues in protein by liquid …

W Chan, YH Ham, L Jin, HW Chan, YL Wong… - Analytical …, 2019 - ACS Publications
Emerging evidence suggests that cross-links formed by reacting DNA lesions with proteins
may play a significant role in the pathophysiology of human cancer and degenerative …

Development of biomimetic enzyme-linked immunosorbent assay based on molecular imprinting technique for semicarbazide detection

W Yu, M Liu, R Liu, Y Sang, S Wang… - Food and Agricultural …, 2020 - Taylor & Francis
Herein, we present a direct competitive biomimetic enzyme-linked immunosorbent assay
(BELISA) method for the determination of semicarbazide (SEM) using a molecularly …