Somatic mutations in cancer cells can generate tumour-specific neoepitopes, which are
recognized by autologous T cells in the host. As neoepitopes are not subject to central …

A fundamental prerequisite for the efficacy of cancer immunotherapy is the presence of
functional, antigen-specific T cells within the tumor. Neoantigen-directed therapy is a …

Neoantigens play a key role in the recognition of tumour cells by T cells; however, only a
small proportion of neoantigens truly elicit T-cell responses, and few clues exist as to which …

Prediction of T-cell receptor (TCR) interactions with MHC-peptide complexes remains highly
challenging. This challenge is primarily due to three dominant factors: data accuracy, data …

Here, we report an update of the VDJdb database with a substantial increase in the number
of T-cell receptor (TCR) sequences and their cognate antigens. The update further provides …

Motivation The activity of the adaptive immune system is governed by T-cells and their
specific T-cell receptors (TCR), which selectively recognize foreign antigens. Recent …

Throughout the body, T cells monitor MHC-bound ligands expressed on the surface of
essentially all cell types. MHC ligands that trigger a T cell immune response are referred to …

Adaptive immune system uses T cell receptors (TCRs) to recognize pathogens and to
consequently initiate immune responses. TCRs can be sequenced from individuals and …

The adaptive immune system in vertebrates has evolved to recognize non-self antigens,
such as proteins expressed by infectious agents and mutated cancer cells. T cells play an …

A central mechanism in machine learning is to identify, store, and recognize patterns. How to
learn, access, and retrieve such patterns is crucial in Hopfield networks and the more recent …