The normal function of poly (ADP-ribose) polymerase-1 (PARP-1) is the routine repair of
DNA damage by adding poly (ADP ribose) polymers in response to a variety of cellular …

The cytotoxic granzyme B (GrB)/perforin pathway has been traditionally viewed as a primary
mechanism that is used by cytotoxic lymphocytes to eliminate allogeneic, virally infected …

The caspase family of cysteine proteases becomes activated in response to diverse cellular
insults and coordinates apoptosis through proteolysis of hundreds of cellular substrates …

Serine proteases form a large family of protein-cleaving enzymes that play an essential role
in processes like blood coagulation, apoptosis and inflammation. Immune cells express a …

Age-related alterations in immunity have been linked to increased incidence of infections
and decreased responses to vaccines in the aging population. Human peripheral blood …

The granzyme B-induced cell death has been traditionally viewed as a primary mechanism
that is used by cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells to eliminate …

Granzymes are a family of serine proteases stored in granules inside cytotoxic cells of the
immune system. Granzyme K (GrK) has been only limitedly characterized and knowledge on …

Human plasmacytoid dendritic cells (pDCs) are crucially involved in the modulation of
adaptive T-cell responses in the course of neoplastic, viral, and autoimmune disorders. In …

Cytotoxic lymphocytes rapidly respond and destroy both malignant cells and cells infected
with intracellular pathogens. One mechanism, known as granule exocytosis, employs the …

Granzyme A (GrA) has long been recognized as one of the key players in the induction of
cell death of neoplastic, foreign or infected cells after granule delivery by cytotoxic cells …