This review provides an update on the current clinical and preclinical understanding of
chemotherapy induced peripheral neuropathy (CIPN). The overview of the clinical syndrome …

Peripheral neuropathies are characterized by nerves damage and axonal loss, and they
could be classified in hereditary or acquired forms. Acquired peripheral neuropathies are …

Millions of new cancer patients receive chemotherapy each year. In addition to killing cancer
cells, chemotherapy is likely to damage rapidly proliferating healthy cells, including the hair …

Background Despite the increasing knowledge of the etiology of neuropathic pain, this type
of chronic pain is resistant to available analgesics in approximately 50% of patients and …

Chemotherapy induced peripheral neuropathy (CIPN), a toxic side effect of some cancer
treatments, negatively impacts patient outcomes and drastically reduces survivor's quality of …

Background: Exploiting synthetic lethality (SL) relationships between protein pairs has
emerged as an important avenue for the development of anti-cancer drugs. Nicotinamide …

Brain cancer and leukemia are the most common cancers diagnosed in the pediatric
population and are often treated with lifesaving chemotherapy. However, chemotherapy …

Several first-line chemotherapeutic agents, including taxanes, platinum agents and
proteasome inhibitors, are associated with the dose-limiting side effect of chemotherapy …

The burdensome condition of chemotherapy-induced peripheral neuropathy occurs with
various chemotherapeutics, including bortezomib, oxaliplatin, paclitaxel and vincristine. The …

A bidirectional relationship exists between hypertension and psychiatric disorders, including
unipolar and bipolar depression, anxiety, post-traumatic stress disorder (PTSD), psychosis …