The innate immune system is the first line of host defense against infection and is comprised
of humoral and cellular mechanisms that recognize potential pathogens within minutes or …

Complement defects are associated with an enhanced risk of a broad spectrum of infectious
as well as systemic or local inflammatory and thrombotic disorders. Inherited complement …

Components of the complement system and atypical parameters of coagulation were
reported in COVID-19 patients, as well as the exacerbation of the inflammation and …

The lectin pathway of the complement system has a pivotal role in the defense against
infectious organisms. After binding of mannan-binding lectin (MBL), ficolins or collectin 11 to …

Mannose-binding lectin-associated serine protease 2 (MASP-2) is the main activator of the
lectin complement pathway and has been suggested to be involved in the pathophysiology …

The Severe acute respiratory syndrome may be caused by coronavirus disease which has
resulted in a global pandemic. Polymorphisms in the population play a role in susceptibility …

Background: Experimental studies have shown that the complement activating enzyme
MASP-2 (mannose-binding lectin associated serine protease 2) exhibits a thrombin-like …

MASP-2 is a key protein of the lectin pathway of complement system. Several MASP2
polymorphisms were associated with MASP-2 serum levels or functional activity. Here we …

The lectin pathway of the complement system can activate the coagulation system in vitro,
but the role of the lectin pathway in haemostatic activation and thrombosis in vivo is not …

Background Pathophysiological mechanisms are still incompletely understood for leprosy,
an urgent public health issue in Brazil. Complement receptor 1 (CR1) binds complement …