Copper is an important trace element that is required for essential enzymes. However, due
to its redox activity, copper can also lead to the generation of toxic reactive oxygen species …

Thiol–disulfide oxidoreductase systems of bacterial cytoplasm and eukaryotic cytosol favor
reducing conditions and protein thiol groups, while bacterial periplasm and eukaryotic …

Copper is an essential trace element for eukaryotes and most prokaryotes. However,
intracellular free copper must be strictly limited because of its toxic side effects. Complex …

Revised and updated, Chemical Reagents for Protein Modification, Third Edition is an
encyclopedic work describing the many approaches to the site-specific modification of …

Wilson disease is an autosomal recessive genetic disorder caused by loss-of-function
mutations in the P-type copper ATPase, ATP7B, which leads to toxic accumulation of copper …

Human Cox17 is a key mitochondrial copper chaperone responsible for supplying copper
ions, through the assistance of Sco1, Sco2, and Cox11, to cytochrome c oxidase, the …

Copper (Cu) and other transition metals are essential for living organisms but also toxic
when present in excess. To cope with this apparent paradox, organisms have developed …

Assembly of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory
chain, requires a concerted activity of a number of chaperones and factors for the insertion of …

Cox17, a copper chaperone for cytochrome-c oxidase, is an essential and highly conserved
protein in eukaryotic organisms. Yeast and mammalian Cox17 share six conserved cysteine …

Stem rot, caused by Sclerotinia sclerotiorum has emerged as one of the major fungal
pathogens of oilseed Brassica across the world. The pathogenic development is exquisitely …