Peroxisome proliferator-activated receptor-α (PPARα), PPARδ and PPARγ are transcription
factors that regulate gene expression following ligand activation. PPARα increases cellular …

Adipose tissues are dynamic tissues that play crucial physiological roles in maintaining
health and homeostasis. Although white adipose tissue and brown adipose tissue are …

Obesity is a worldwide epidemic that predisposes individuals to cardiometabolic
complications, such as type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease …

Mammalian adipose tissue is traditionally categorized into white and brown relating to their
function and morphology: while white serves as an energy storage, brown adipose tissue …

Fatty acids (FAs) activate and fuel UCP1-mediated non-shivering thermogenesis (NST) in
brown adipose tissue (BAT). Release of FAs from intracellular fat stores by adipose …

The number and activity of brown adipocytes are linked to the ability of mammals to resist
body fat accumulation. In some conditions, certain white adipose tissue (WAT) depots are …

Certain white adipose tissue (WAT) depots are readily able to convert to a “brown-like” state
with prolonged cold exposure or exposure to β-adrenergic compounds. This process is …

The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Brown adipose tissue (BAT) is a major site of nonshivering thermogenesis in mammals.
Rodent studies indicated that BAT thermogenic activity may protect against obesity. Recent …

Adipose tissue plays a central role in regulating whole-body energy and glucose
homeostasis through its subtle functions at both organ and systemic levels. On one hand …