How does high DHA fish oil affect health? A systematic review of evidence

S Ghasemi Fard, F Wang, AJ Sinclair… - Critical reviews in …, 2019 - Taylor & Francis
The health benefits of fish oil, and its omega-3 long chain polyunsaturated fatty acid content,
have attracted much scientific attention in the last four decades. Fish oils that contain higher …

The differential effects of eicosapentaenoic acid and docosahexaenoic acid on cardiometabolic risk factors: a systematic review

JK Innes, PC Calder - International journal of molecular sciences, 2018 - mdpi.com
A large body of evidence supports the cardioprotective effects of the long-chain omega-3
polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA), and docosahexaenoic …

Blood omega-3 fatty acids and death from COVID-19: A pilot study

A Asher, NL Tintle, M Myers, L Lockshon… - … and Essential Fatty …, 2021 - Elsevier
Very-long chain omega-3 fatty acids (EPA and DHA) have anti-inflammatory properties that
may help reduce morbidity and mortality from COVID-19 infection. We conducted a pilot …

Updates to the n-3 polyunsaturated fatty acid biosynthesis pathway: DHA synthesis rates, tetracosahexaenoic acid and (minimal) retroconversion

AH Metherel, RP Bazinet - Progress in Lipid Research, 2019 - Elsevier
N-3 polyunsaturated fatty acids (PUFA) and the numerous families of lipid mediators derived
from them collectively regulate numerous biological processes. The mechanisms by which n …

[HTML][HTML] Compound-specific isotope analysis reveals no retroconversion of DHA to EPA but substantial conversion of EPA to DHA following supplementation: a …

AH Metherel, M Irfan, SL Klingel, DM Mutch… - The American journal of …, 2019 - Elsevier
Background It has long been believed that DHA supplementation increases plasma EPA via
the retroconversion pathway in mammals. However, in rodents this increase in EPA is likely …

The influence of dietary and supplemental omega-3 fatty acids on the omega-3 index: A scoping review

M Dempsey, MS Rockwell, LM Wentz - Frontiers in Nutrition, 2023 - frontiersin.org
Introduction The majority of the population do not consume adequate omega-3 fatty acids (n-
3 FA), leading to global deficiencies, as evidenced by poor omega-3 status. An indicator of …

[HTML][HTML] Predicting the effects of supplemental EPA and DHA on the omega-3 index

RE Walker, KH Jackson, NL Tintle, GC Shearer… - The American journal of …, 2019 - Elsevier
Background Supplemental long-chain omega-3 (n–3) fatty acids (EPA and DHA) raise
erythrocyte EPA+ DHA [omega-3 index (O3I)] concentrations, but the magnitude or variability …

Brain eicosapentaenoic acid metabolism as a lead for novel therapeutics in major depression

RP Bazinet, AH Metherel, CT Chen, SR Shaikh… - Brain, behavior, and …, 2020 - Elsevier
The results of several meta-analyses suggest that eicosapentaenoic acid (EPA)
supplementation is therapeutic in managing the symptoms of major depression. It was …

Injectable liposomal docosahexaenoic acid alleviates atherosclerosis progression and enhances plaque stability

SY Chong, X Wang, L van Bloois… - … Clinics and Research, 2023 - journals.lww.com
Atherosclerosis is a chronic inflammatory vascular disease that is characterized by the
accumulation of lipids and immune cells in plaques built up inside artery walls …

Omega-3 Eicosapentaenoic Acid (EPA) Rich Extract from the Microalga Nannochloropsis Decreases Cholesterol in Healthy Individuals: A Double-Blind, Randomized …

A Rao, D Briskey, JO Nalley, E Ganuza - Nutrients, 2020 - mdpi.com
The aim of this trial is to assess the effect of Almega® PL on improving the Omega-3 Index,
cardio-metabolic parameters, and other biomarkers in generally healthy individuals. The …