Wide-field optical mapping of neural activity and brain haemodynamics: considerations and novel approaches
Although modern techniques such as two-photon microscopy can now provide cellular-level
three-dimensional imaging of the intact living brain, the speed and fields of view of these …
three-dimensional imaging of the intact living brain, the speed and fields of view of these …
A resurging boom in new drugs for epilepsy and brain disorders
Introduction: Epilepsy is one of the most common neurological diseases affecting
approximately 50 million people worldwide. Despite many advances in epilepsy research …
approximately 50 million people worldwide. Despite many advances in epilepsy research …
Mesoscale mapping of mouse cortex reveals frequency-dependent cycling between distinct macroscale functional modules
Connectivity mapping based on resting-state activity in mice has revealed functional motifs
of correlated activity. However, the rules by which motifs organize into larger functional …
of correlated activity. However, the rules by which motifs organize into larger functional …
[HTML][HTML] Gabrb3 is required for the functional integration of pyramidal neuron subtypes in the somatosensory cortex
Dysfunction of gamma-aminobutyric acid (GABA) ergic circuits is strongly associated with
neurodevelopmental disorders. However, it is unclear how genetic predispositions impact …
neurodevelopmental disorders. However, it is unclear how genetic predispositions impact …
Deep two-photon brain imaging with a red-shifted fluorometric Ca2+ indicator
C Tischbirek, A Birkner, H Jia… - Proceedings of the …, 2015 - National Acad Sciences
In vivo Ca2+ imaging of neuronal populations in deep cortical layers has remained a major
challenge, as the recording depth of two-photon microscopy is limited because of the …
challenge, as the recording depth of two-photon microscopy is limited because of the …
Role of inhibitory control in modulating focal seizure spread
Focal seizure propagation is classically thought to be spatially contiguous. However,
distribution of seizures through a large-scale epileptic network has been theorized. Here, we …
distribution of seizures through a large-scale epileptic network has been theorized. Here, we …
Understanding the neurovascular unit at multiple scales: advantages and limitations of multi-photon and functional ultrasound imaging
Developing efficient brain imaging technologies by combining a high spatiotemporal
resolution and a large penetration depth is a key step for better understanding the …
resolution and a large penetration depth is a key step for better understanding the …
Glial calcium waves are triggered by seizure activity and not essential for initiating ictal onset or neurovascular coupling
E Baird-Daniel, AGS Daniel, M Wenzel, D Li… - Cerebral …, 2017 - academic.oup.com
It has been postulated that glia play a critical role in modifying neuronal activity, mediating
neurovascular coupling, and in seizure initiation. We investigated the role of glia in …
neurovascular coupling, and in seizure initiation. We investigated the role of glia in …
Isoflurane-induced burst suppression is a thalamus-modulated, focal-onset rhythm with persistent local asynchrony and variable propagation patterns in rats
Q Ming, JY Liou, F Yang, J Li, C Chu, Q Zhou… - Frontiers in Systems …, 2021 - frontiersin.org
Background: Inhalational anesthetic-induced burst suppression (BS) is classically
considered a bilaterally synchronous rhythm. However, local asynchrony has been …
considered a bilaterally synchronous rhythm. However, local asynchrony has been …
Cocaine attenuates blood flow but not neuronal responses to stimulation while preserving neurovascular coupling for resting brain activity
Cocaine affects neuronal activity and constricts cerebral blood vessels, making it difficult to
determine whether cocaine-induced changes in cerebral blood flow (CBF) reflect neuronal …
determine whether cocaine-induced changes in cerebral blood flow (CBF) reflect neuronal …