Mitophagy plays a central role in mitochondrial ageing
A Diot, K Morten, J Poulton - Mammalian Genome, 2016 - Springer
The mechanisms underlying ageing have been discussed for decades, and advances in
molecular and cell biology of the last three decades have accelerated research in this area …
molecular and cell biology of the last three decades have accelerated research in this area …
The mitochondrial side of epigenetics
A Castegna, V Iacobazzi… - Physiological …, 2015 - journals.physiology.org
The bidirectional cross talk between nuclear and mitochondrial DNA is essential for cellular
homeostasis and proper functioning. Mitochondria depend on nuclear contribution for much …
homeostasis and proper functioning. Mitochondria depend on nuclear contribution for much …
Epigenome-wide association study identifies cardiac gene patterning and a novel class of biomarkers for heart failure
Background: Biochemical DNA modification resembles a crucial regulatory layer among
genetic information, environmental factors, and the transcriptome. To identify epigenetic …
genetic information, environmental factors, and the transcriptome. To identify epigenetic …
Detection of differentially methylated gene promoters in failing and nonfailing human left ventricle myocardium using computation analysis
Human dilated cardiomyopathy (DCM) is characterized by congestive heart failure and
altered myocardial gene expression. Epigenetic changes, including DNA methylation, are …
altered myocardial gene expression. Epigenetic changes, including DNA methylation, are …
The emergence of the mitochondrial genome as a partial regulator of nuclear function is providing new insights into the genetic mechanisms underlying age-related …
Mitochondrial malfunction appears to be intimately associated with age and age-related
complex disorders but the precise pathological relevance of such malfunction remains …
complex disorders but the precise pathological relevance of such malfunction remains …
Strand displacement–triggered FRET nanoprobe tracking TK1 mRNA in living cells for ratiometric fluorimetry of nucleic acid biomarker
F Dong, W Yan, M Qu, X Shang, W Dong, Z Lu… - Microchimica Acta, 2024 - Springer
A precisely designed dual-color biosensor has realized a visual assessment of thymidine
kinase 1 (TK1) mRNA in both living cells and cell lysates. The oligonucleotide probe is …
kinase 1 (TK1) mRNA in both living cells and cell lysates. The oligonucleotide probe is …
Genetic aspects of the oxidative phosphorylation dysfunction in dilated cardiomyopathy
MP Bayona-Bafaluy, E Iglesias… - … Research/Reviews in …, 2020 - Elsevier
Dilated cardiomyopathy is a frequent and extremely heterogeneous medical condition.
Deficits in the oxidative phosphorylation system have been described in patients suffering …
Deficits in the oxidative phosphorylation system have been described in patients suffering …
AZT-induced mitochondrial toxicity: an epigenetic paradigm for dysregulation of gene expression through mitochondrial oxidative stress
CA Koczor, Z Jiao, E Fields, R Russ… - Physiological …, 2015 - journals.physiology.org
Mitochondrial dysfunction causes oxidative stress and cardiomyopathy. Oxidative stress also
is a side effect of dideoxynucleoside antiretrovirals (NRTI) and is observed in NRTI-induced …
is a side effect of dideoxynucleoside antiretrovirals (NRTI) and is observed in NRTI-induced …
Mitochondrial polymerase gamma dysfunction and aging cause cardiac nuclear DNA methylation changes
CA Koczor, I Ludlow, E Fields, Z Jiao… - Physiological …, 2016 - journals.physiology.org
Cardiomyopathy (CM) is an intrinsic weakening of myocardium with contractile dysfunction
and congestive heart failure (CHF). CHF has been postulated to result from decreased …
and congestive heart failure (CHF). CHF has been postulated to result from decreased …
Identification of Signature Genes of Dilated Cardiomyopathy Using Integrated Bioinformatics Analysis
Z Wu, X Wang, H Liang, F Liu, Y Li, H Zhang… - International Journal of …, 2023 - mdpi.com
Dilated cardiomyopathy (DCM) is characterized by left ventricular or biventricular
enlargement with systolic dysfunction. To date, the underlying molecular mechanisms of …
enlargement with systolic dysfunction. To date, the underlying molecular mechanisms of …