Oligomers which form during amyloid fibril assembly are considered to be key contributors
towards amyloid disease. However, understanding how such intermediates form, their …

Mass spectrometry (MS) is increasingly being used to probe the structure and dynamics of
proteins and the complexes they form with other macromolecules. There are now several …

We present a cross-linking/mass spectrometry workflow for performing proteome-wide cross-
linking analyses within 1 week. The workflow is based on the commercially available mass …

Protein-protein interactions govern most cellular pathways and processes, and multiple
technologies have emerged to systematically map them. Assessing the error of interaction …

Chemical crosslinking‐mass spectrometry (XL‐MS) is a valuable technique for gaining
insights into protein structure and the organization of macromolecular complexes. XL‐MS …

A diazirine‐based four‐armed cross‐linker (4CNN) with a tetrahedron geometry is
presented for efficient patterning of polymeric semiconductors by photo‐induced carbene …

Aryl trifluoromethyl diazoalkanes and diazirines have become unique as reactants in
synthetic methodology. As privileged compounds containing CF3 groups and ease of …

The periplasmic chaperone SurA plays a key role in outer membrane protein (OMP)
biogenesis. E. coli SurA comprises a core domain and two peptidylprolyl isomerase …

Structural proteomics refers to large‐scale mapping of protein structures in order to
understand the relationship between protein sequence, structure, and function. Chemical …

After the first seed concept introduced in the 18th century, different disciplines have
attributed different names to dual-functional molecules depending on their application …