Intranasal delivery of mesenchymal stem cell-derived extracellular vesicles exerts immunomodulatory and neuroprotective effects in a 3xTg model of Alzheimer's …

M Losurdo, M Pedrazzoli, C D'Agostino… - Stem cells …, 2020 - academic.oup.com
The critical role of neuroinflammation in favoring and accelerating the pathogenic process in
Alzheimer's disease (AD) increased the need to target the cerebral innate immune cells as a …

Multi-extremum-modified response basis model for nonlinear response prediction of dynamic turbine blisk

B Keshtegar, M Bagheri, CW Fei, C Lu… - Engineering with …, 2021 - Springer
For the nonlinear dynamic analyses of complex mechanical components, it is necessary to
apply efficient modeling framework to reduce computational burden. The accurate surrogate …

Local action of cytokines and immune cells in communication between the conceptus and uterus during the critical period of early embryo development, attachment …

G Campanile, PS Baruselli, A Limone, JD Michael - Theriogenology, 2021 - Elsevier
Early embryo development, implantation and pregnancy involve a complex dialogue
between the embryo and mother. In cattle this dialogue starts as early as days 3–4 when the …

Sperm activate TLR2/TLR1 heterodimerization to induce a weak proinflammatory response in the bovine uterus

A Mansouri, MS Yousef, R Kowsar, N Usui… - Frontiers in …, 2023 - frontiersin.org
Toll-like receptor 2 (TLR2) signaling pathway is involved in the sperm-triggered uterine
inflammatory response at insemination, but its precise mechanism at molecular-level …

SVR-RSM: a hybrid heuristic method for modeling monthly pan evaporation

B Keshtegar, S Heddam, A Sebbar, SP Zhu… - … Science and Pollution …, 2019 - Springer
In the present study, a hybrid intelligent model called SVR_RSM, which was extracted using
response surface method (RSM) combined by the support vector regression (SVR) …

Multi-level analysis reveals the association between diabetes, body mass index, and HbA1c in an Iraqi population

R Kowsar, A Mansouri - Scientific Reports, 2022 - nature.com
Abstract Type 2 diabetes (T2D) known as a complex metabolic disorder may cause health
problems and changes in blood biochemical markers. A growing number of studies have …

The impact of calcitriol and estradiol on the SARS-CoV-2 biological activity: A molecular modeling approach

A Mansouri, R Kowsar, M Zakariazadeh, H Hakimi… - Scientific Reports, 2022 - nature.com
The novel coronavirus disease (COVID-19) is currently a big concern around the world.
Recent reports show that the disease severity and mortality of COVID-19 infected patients …

Towards a comprehensive assessment of statistical versus soft computing models in hydrology: Application to monthly pan evaporation prediction

M Zounemat-Kermani, B Keshtegar, O Kisi, M Scholz - Water, 2021 - mdpi.com
This paper evaluates six soft computational models along with three statistical data-driven
models for the prediction of pan evaporation (EP). Accordingly, improved kriging—as a …

AK-GWO: a novel hybrid optimization method for accurate optimum hierarchical stiffened shells

R Kolahchi, K Tian, B Keshtegar, Z Li, NT Trung… - Engineering with …, 2020 - Springer
The efficiency as computational efforts and accuracy as optimum design condition are two
major changes in hybrid intelligent optimization methods for hierarchical stiffened shells …

Role of N6‐methyladenosine RNA modification in the imbalanced inflammatory homeostasis of arsenic‐induced skin lesions

F Yang, A Zhang - Environmental Toxicology, 2022 - Wiley Online Library
This study aimed to investigate the effect of N6‐methyladenosine (m6A) modification in
modulating inflammatory homeostasis of arsenic (As)‐induced skin lesions. Our …