Natural macromolecules, such as proteins and nucleic acids, display various complex
functionalities in biological systems. These functionalities depend on the macromolecular …

A grand challenge in the field of structural biology is to design and engineer proteins that
exhibit targeted functions. Although much success on this front has been achieved, design …

Non-natural folded polymers (foldamers) display considerable versatility, and the design of
such molecules is of great current interest. In this respect, peptidic foldamers are perhaps …

Summarizing the implications of homochiral structures in interpeptide interactions, not only
in the topology but also possibly in the physics of protein folding, this Account provides an …

We use a de Novo protein design strategy to demonstrate that the second coordination
sphere of a metal site plays a key role in controlling coordination geometries of Cd (II)-tris …

A small peptide stereochemically customized as a globular fold with a molecular cleft - Chemical
Communications (RSC Publishing) DOI:10.1039/B413802C Royal Society of Chemistry View …

Natural proteins are concatenated amino acids with definite handedness or chirality, with
their spatial orientation being preferentially left handed or l-chiral. This paper discusses the …

The protein‐structure space is limited to l configuration in the asymmetric α‐amino acid
structures; the function space, on other hand, seems limitless because of the chemical …

Although metal ion binding to naturally occurring l‐amino acid proteins is well documented,
understanding the impact of the opposite chirality (d‐) amino acids on the structure and …

Stereochemistry limits but also defines proteins, as conformational constructs stereospecific
for poly-l structure. Employed as a variable in sequence, stereochemistry could make …