Neuroprotective Effect of Clemastine Improved Oligodendrocyte Proliferation through the MAPK/ERK Pathway in a Neonatal Hypoxia Ischemia Rat Model

ME Bernis, C Hakvoort, E Nacarkucuk… - … journal of molecular …, 2024 - pmc.ncbi.nlm.nih.gov
Neonatal hypoxic-ischemic encephalopathy is the most common cause of long-term
disability in term neonates, and white matter injury is the primary cause of cerebral palsy …

Effects of regional brain volumes on cognition in sickle cell anemia: A developmental perspective

S Hamdule, M Kölbel, H Stotesbury, R Murdoch… - Frontiers in …, 2023 - frontiersin.org
Background and objectives Cognitive difficulties in people with sickle cell anemia (SCA) are
related to lower processing speed index (PSI) and working memory index (WMI). However …

Subcortical brain volumes in neonatal hypoxic–ischemic encephalopathy

LMN Kebaya, B Kapoor, PC Mayorga, P Meyerink… - Pediatric …, 2023 - nature.com
Background Despite treatment with therapeutic hypothermia, hypoxic–ischemic
encephalopathy (HIE) is associated with adverse developmental outcomes, suggesting the …

Mammillary body abnormalities and cognitive outcomes in children cooled for neonatal encephalopathy

APC Spencer, MH Lequin, LS De Vries… - … Medicine & Child …, 2023 - Wiley Online Library
Aim To evaluate mammillary body abnormalities in school‐age children without cerebral
palsy treated with therapeutic hypothermia for neonatal hypoxic–ischaemic encephalopathy …

Early assessment of injury with optical markers in a piglet model of neonatal encephalopathy

K Harvey-Jones, F Lange, V Verma, G Bale… - Pediatric …, 2023 - nature.com
Background Opportunities for adjunct therapies with cooling in neonatal encephalopathy are
imminent; however, robust biomarkers of early assessment are lacking. Using an optical …

[HTML][HTML] Therapeutic Hypothermia and Its Role in Preserving Brain Volume in Term Neonates with Perinatal Asphyxia

HF García Arias, GL Porras-Hurtado… - Journal of Clinical …, 2024 - mdpi.com
Background: Perinatal asphyxia is a major cause of neonatal morbidity and mortality, often
resulting in hypoxic-ischemic encephalopathy (HIE) with long-term neurodevelopmental …

Hippocampus and hypothermia: A missing link

P Montaldo, S Thayyil - Developmental Medicine and Child …, 2023 - ncbi.nlm.nih.gov
While therapeutic hypothermia improves outcome after moderate and severe neonatal
hypoxic-ischaemic encephalopathy (HIE) in high-income countries, many cooled infants …

Resting-state functional connectivity in children cooled for neonatal encephalopathy

APC Spencer, M Goodfellow… - Brain …, 2024 - academic.oup.com
Therapeutic hypothermia improves outcomes following neonatal hypoxic-ischaemic
encephalopathy, reducing cases of death and severe disability such as cerebral palsy …

[HTML][HTML] A Systematic Review of the Relationship Between Neonatal Hypoxic-Ischemic Encephalopathy and Long-Term Cognitive Outcomes: Where Do We Stand?

MY Abusaleem, MEE Ebrahim, NF Hamed… - Cureus, 2024 - pmc.ncbi.nlm.nih.gov
This study aims to systematically review the existing literature on long-term cognitive
outcomes in neonates with hypoxic-ischemic encephalopathy (HIE). A thorough search of …

[PDF][PDF] BRAIN COMMUNICATIONS

APC Spencer, M Goodfellow, E Chakkarapani… - 2024 - ore.exeter.ac.uk
Therapeutic hypothermia has considerably improved outcomes following neonatal hypoxic-
ischaemic encephalopathy (HIE) secondary to perinatal asphyxia. Cooled infants are at …