Cytochrome c (cyt c) is a small soluble heme protein characterized by a relatively flexible
structure, particularly in the ferric form, such that it is able to sample a broad conformational …

Biomolecules are the prime information processing elements of living matter. Most of these
inanimate systems are polymers that compute their own structures and dynamics using as …

The distances over which biological molecules and their complexes can function range from
a few nanometres, in the case of folded structures, to millimetres, for example, during …

Cytochrome c (cyt c) is a cationic hemoprotein of∼ 100 amino acid residues that exhibits
exceptional functional versatility. While its primary function is electron transfer in the …

Allostery is a phenomenon that couples effector ligand binding at an allosteric site to a
structural and/or dynamic change at a distant regulated site. To study an allosteric transition …

The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. This talk will provide
an overview of new approaches to study and manipulate signaling in living cells and …

Biological processes are the result of noncovalent, protein–ligand interactions, where the
ligands range from small organic and inorganic molecules to lipids, nucleic acids, peptides …

Precision oncology benefits from effective early phase drug discovery decisions. Recently,
drugging inactive protein conformations has shown impressive successes, raising the …

Significance: An ancient anionic phospholipid, cardiolipin (CL), ubiquitously present in
prokaryotic and eukaryotic membranes, is essential for several structural and functional …

Heme proteins perform various biological functions ranging from electron transfer, oxygen
binding and transport, catalysis, to signaling. Although adopting proper native states is very …