Skeletal elements have a diverse range of shapes and sizes specialized to their various
roles including protecting internal organs, locomotion, feeding, hearing, and vocalization …

Cardiovascular diseases represent a major cause of morbidity and mortality, necessitating
research to improve diagnostics, and to discover and test novel preventive and curative …

Targeted protein degradation methods offer a unique avenue to assess a protein's function
in a variety of model systems. Recently, these approaches have been applied to mammalian …

Abstract The Cre–LoxP system provides a widely used method for studying gene
requirements in the mouse as the main mammalian genetic model organism. To define the …

Site-specific recombinases (SSRs) are invaluable genome engineering tools that have
enormously boosted our understanding of gene functions and cell lineage relationships in …

The thymus medulla is a key site for immunoregulation and tolerance, and its functional
specialisation is achieved through the complexity of medullary thymic epithelial cells …

ABSTRACT The Cre/Lox system is a powerful tool in the biologist's toolbox, allowing loss‐of‐
function and gain‐of‐function studies, as well as lineage tracing, through gene …

Lymphatic vessels have critical roles in both health and disease and their study is a rapidly
evolving area of vascular biology. The consensus on how the first lymphatic vessels arise in …

Post-zygotic mutations that generate tissue mosaicism are increasingly associated with
severe congenital defects, including those arising from failed neural tube closure. Here we …

Inducible Cre-dependent systems are frequently used to produce both conditional knockouts
and transgenic mice with regulated expression of the gene of interest. Induction can be …