The impact of molecular dynamics (MD) simulations in molecular biology and drug discovery
has expanded dramatically in recent years. These simulations capture the behavior of …

The concentration of glucose in plasma is held within narrow limits (4–10 mmol/l), primarily
to ensure fuel supply to the brain. Kidneys play a role in glucose homeostasis in the body by …

Human sodium–glucose cotransporter 2 (hSGLT2) mediates the reabsorption of the majority
of filtrated glucose in the kidney. Pharmacological inhibition of hSGLT2 by oral small …

Solute carrier (SLC) membrane transport proteins control essential physiological functions,
including nutrient uptake, ion transport, and waste removal. SLCs interact with several …

The determination of the crystal structures of small-molecule transporters has shed light on
the conformational changes that take place during structural isomerization from outward-to …

SGLTs are sodium glucose transporters found on the luminal membrane of the proximal
tubule, where they reabsorb some 180 g (1 mol) of glucose from the glomerular filtrate each …

There are two classes of glucose transporters involved in glucose homeostasis in the body,
the facilitated transporters or uniporters (GLUTs) and the active transporters or symporters …

Traditional treatments for type 1 and type 2 diabetes are often associated with side effects,
including weight gain and hypoglycaemia that may offset the benefits of blood glucose …

Soluble sugars serve five main purposes in multicellular organisms: as sources of carbon
skeletons, osmolytes, signals, and transient energy storage and as transport molecules …

The neurotransmitter transporters (NTTs) belonging to the solute carrier 6 (SLC6) gene
family (also referred to as the neurotransmitter-sodium-symporter family or Na+/Cl …