Polycystic ovary syndrome: pathophysiology, presentation, and treatment with emphasis on adolescent girls

SF Witchel, SE Oberfield, AS Peña - Journal of the Endocrine …, 2019 - academic.oup.com
Polycystic ovary syndrome (PCOS) is a heterogeneous disorder characterized by
hyperandrogenism and chronic anovulation. Depending on diagnostic criteria, 6% to 20% of …

Animal models to understand the etiology and pathophysiology of polycystic ovary syndrome

E Stener-Victorin, V Padmanabhan… - Endocrine …, 2020 - academic.oup.com
More than 1 out of 10 women worldwide are diagnosed with polycystic ovary syndrome
(PCOS), the leading cause of female reproductive and metabolic dysfunction. Despite its …

Androgen excess fetal programming of female reproduction: a developmental aetiology for polycystic ovary syndrome?

DH Abbott, DK Barnett, CM Bruns… - Human reproduction …, 2005 - academic.oup.com
The aetiology of polycystic ovary syndrome (PCOS) remains unknown. This familial
syndrome is prevalent among reproductive-aged women and its inheritance indicates a …

Definitions, prevalence and symptoms of polycystic ovaries and polycystic ovary syndrome

R Hart, M Hickey, S Franks - Best Practice & Research Clinical Obstetrics & …, 2004 - Elsevier
Polycystic ovarian morphology is seen on ultrasound in approximately 22% of women.
Polycystic ovary syndrome (PCOS) is a common and perplexing endocrine disorder of …

Is foetal hyperexposure to androgens a cause of PCOS?

P Filippou, R Homburg - Human Reproduction Update, 2017 - academic.oup.com
BACKGROUND Polycystic ovary syndrome (PCOS) is the most common endocrinopathy
affecting reproductive-aged women. The pathophysiology of this syndrome is still not …

Polycystic ovary syndrome and its developmental origins

DA Dumesic, DH Abbott, V Padmanabhan - Reviews in Endocrine and …, 2007 - Springer
The prenatal testosterone (T)-treated adult female rhesus monkey is one animal model of
polycystic ovary syndrome (PCOS) in women, with early prenatal T excess programming a …

Sheep models of polycystic ovary syndrome phenotype

V Padmanabhan, A Veiga-Lopez - Molecular and cellular endocrinology, 2013 - Elsevier
Polycystic ovary syndrome (PCOS) is a fertility disorder affecting 5–7% of reproductive-aged
women. Women with PCOS manifest both reproductive and metabolic defects. Several …

Prenatal androgens alter GABAergic drive to gonadotropin-releasing hormone neurons: implications for a common fertility disorder

SD Sullivan, SM Moenter - Proceedings of the National …, 2004 - National Acad Sciences
Polycystic ovary syndrome, a fertility disorder affecting≈ 7% of women, is characterized by
elevated androgens, disrupted reproductive cycles, and high luteinizing hormone, the latter …

Fetal programming: prenatal testosterone excess leads to fetal growth retardation and postnatal catch-up growth in sheep

M Manikkam, EJ Crespi, DD Doop, C Herkimer… - …, 2004 - academic.oup.com
Alterations in the maternal endocrine, nutritional, and metabolic environment disrupt the
developmental trajectory of the fetus, leading to adult diseases. Female offspring of rats …

Developmental programming and endocrine disruptor effects on reproductive neuroendocrine systems

AC Gore - Frontiers in neuroendocrinology, 2008 - Elsevier
The ability of a species to reproduce successfully requires the careful orchestration of
developmental processes during critical time points, particularly the late embryonic and …