Quantifying behavior to understand the brain

TD Pereira, JW Shaevitz, M Murthy - Nature neuroscience, 2020 - nature.com
Over the past years, numerous methods have emerged to automate the quantification of
animal behavior at a resolution not previously imaginable. This has opened up a new field of …

Computational neuroethology: a call to action

SR Datta, DJ Anderson, K Branson, P Perona, A Leifer - Neuron, 2019 - cell.com
The brain is worthy of study because it is in charge of behavior. A flurry of recent technical
advances in measuring and quantifying naturalistic behaviors provide an important …

Unsupervised identification of the internal states that shape natural behavior

AJ Calhoun, JW Pillow, M Murthy - Nature neuroscience, 2019 - nature.com
Internal states shape stimulus responses and decision-making, but we lack methods to
identify them. To address this gap, we developed an unsupervised method to identify …

Neural circuit mechanisms of sexual receptivity in Drosophila females

K Wang, F Wang, N Forknall, T Yang, C Patrick… - Nature, 2021 - nature.com
Choosing a mate is one of the most consequential decisions a female will make during her
lifetime. A female fly signals her willingness to mate by opening her vaginal plates, allowing …

Ventromedial prefrontal neurons represent self-states shaped by vicarious fear in male mice

Z Huang, M Chung, K Tao, A Watarai, MY Wang… - Nature …, 2023 - nature.com
Perception of fear induced by others in danger elicits complex vicarious fear responses and
behavioral outputs. In rodents, observing a conspecific receive aversive stimuli leads to …

Drosophila sensory receptors—a set of molecular Swiss Army Knives

C Montell - Genetics, 2021 - academic.oup.com
Genetic approaches in the fruit fly, Drosophila melanogaster, have led to a major triumph in
the field of sensory biology—the discovery of multiple large families of sensory receptors …

Rapid reconstruction of neural circuits using tissue expansion and light sheet microscopy

JL Lillvis, H Otsuna, X Ding, I Pisarev, T Kawase… - Elife, 2022 - elifesciences.org
Brain function is mediated by the physiological coordination of a vast, intricately connected
network of molecular and cellular components. The physiological properties of neural …

The natverse, a versatile toolbox for combining and analysing neuroanatomical data

AS Bates, JD Manton, SR Jagannathan, M Costa… - Elife, 2020 - elifesciences.org
To analyse neuron data at scale, neuroscientists expend substantial effort reading
documentation, installing dependencies and moving between analysis and visualisation …

Activity of nested neural circuits drives different courtship songs in Drosophila

HM Shiozaki, K Wang, JL Lillvis, M Xu… - Nature …, 2024 - nature.com
Motor systems implement diverse motor programs to pattern behavioral sequences, yet how
different motor actions are controlled on a moment-by-moment basis remains unclear. Here …

Drosophila sechellia: A Genetic Model for Behavioral Evolution and Neuroecology

TO Auer, MP Shahandeh… - Annual Review of Genetics, 2021 - annualreviews.org
Defining the mechanisms by which animals adapt to their ecological niche is an important
problem bridging evolution, genetics, and neurobiology. We review the establishment of a …