Water solubility and structural stability are key merits for proteins defined by the primary
sequence and 3D-conformation. Their manipulation represents important aspects of the …

Natural metalloproteins perform many functions—ranging from sensing to electron transfer
and catalysis—in which the position and property of each ligand and metal are dictated by …

Proteins are molecular machines whose function depends on their ability to achieve
complex folds with precisely defined structural and dynamic properties. The rational design …

One of the hallmark advances in our understanding of metalloprotein function is showcased
in our ability to design new, non-native, catalytically active protein scaffolds. This review …

Self-assembly of molecules often results in new emerging properties. Even very short
peptides can self-assemble into structures with a variety of physical and structural …

Recent developments in computational chemistry and biology have come together in the
“inside‐out” approach to enzyme engineering. Proteins have been designed to catalyze …

Protein design is a valuable tool for understanding the fundamental factors that dictate
protein structure and function. The field of protein design has seen significant progress over …

Transition metals function as structural and catalytic cofactors for a large diversity of proteins
and enzymes that collectively comprise the metalloproteome. Metallostasis considers all …

Peptides and their conjugates (to lipids, bulky N-terminals, or other groups) can self-
assemble into nanostructures such as fibrils, nanotubes, coiled coil bundles, and micelles …

The design of artificial enzymes has emerged as a promising tool for the generation of
potent biocatalysts able to promote new‐to‐nature reactions with improved catalytic …