Towards next-generation diagnostic pathology: AI-empowered label-free multiphoton microscopy

S Wang, J Pan, X Zhang, Y Li, W Liu, R Lin… - Light: Science & …, 2024 - nature.com
Diagnostic pathology, historically dependent on visual scrutiny by experts, is essential for
disease detection. Advances in digital pathology and developments in computer vision …

Imaging approaches for monitoring three‐dimensional cell and tissue culture systems

G Hilzenrat, ET Gill, SL McArthur - Journal of Biophotonics, 2022 - Wiley Online Library
The past decade has seen an increasing demand for more complex, reproducible and
physiologically relevant tissue cultures that can mimic the structural and biological features …

In vivo microscopy as an adjunctive tool to guide detection, diagnosis, and treatment

KW Bishop, KC Maitland… - … of Biomedical Optics, 2022 - spiedigitallibrary.org
Significance: There have been numerous academic and commercial efforts to develop high-
resolution in vivo microscopes for a variety of clinical use cases, including early disease …

Self-supervised deep-learning two-photon microscopy

Y He, J Yao, L Liu, Y Gao, J Yu, S Ye, H Li… - Photonics …, 2022 - opg.optica.org
Artificial neural networks have shown great proficiency in transforming low-resolution
microscopic images into high-resolution images. However, training data remains a …

Harnessing artificial intelligence to reduce phototoxicity in live imaging

E Gómez-de-Mariscal, M Del Rosario… - Journal of Cell …, 2024 - journals.biologists.com
Fluorescence microscopy is essential for studying living cells, tissues and organisms.
However, the fluorescent light that switches on fluorescent molecules also harms the …

Vitreoretinal surgical instrument tracking in three dimensions using deep learning

PF Baldi, S Abdelkarim, J Liu, JK To… - … vision science & …, 2023 - tvst.arvojournals.org
Purpose: To evaluate the potential for artificial intelligence-based video analysis to
determine surgical instrument characteristics when moving in the three-dimensional vitreous …

Tutorial: multiphoton microscopy to advance neuroscience research

IC Hernández, J Yau, L Rishøj, N Cui… - … and Applications in …, 2023 - iopscience.iop.org
Multiphoton microscopy (MPM) employs ultrafast infrared lasers for high-resolution deep
three-dimensional imaging of live biological samples. The goal of this tutorial is to provide a …

AI‐organoid integrated systems for biomedical studies and applications

S Maramraju, A Kowalczewski, A Kaza… - Bioengineering & …, 2024 - Wiley Online Library
In this review, we explore the growing role of artificial intelligence (AI) in advancing the
biomedical applications of human pluripotent stem cell (hPSC)‐derived organoids. Stem cell …

人工智能在类器官研究中的应用进展与挑战

吴洪基, 王海霞, 汪玲, 罗小刚, 邹冬玲 - 中国癌症杂志, 2024 - china-oncology.com
类器官是一种优异的肿瘤和干细胞研究模型, 对其生长或药筛等过程的各种类型数据进行分析,
有助于提升对类器官本身以及所代表疾病的了解. 但人工观察和筛选类器官以及使用传统统计学 …

Label-free characterization of pathological changes in the portal area of liver fibrosis tissue using multiphoton imaging and quantitative image analysis

X Zhang, YE Lian, XB Yu, X Huang… - Journal of Physics D …, 2024 - iopscience.iop.org
Liver fibrosis plays a crucial role in the progression of liver diseases and serves as a pivotal
stage leading to the development of liver cirrhosis and cancer. It typically initiates from portal …