Successful vaccine development for infectious diseases has largely been achieved in
settings where natural immunity to the pathogen results in clearance in at least some …

The HCP5 RNA gene (NCBI ID: 10866) is located centromeric of the HLA-B gene and
between the MICA and MICB genes within the major histocompatibility complex (MHC) class …

To extend the understanding of host genetic determinants of HIV-1 control, we performed a
genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study …

We performed a whole-genome association study of human immunodeficiency virus type 1
(HIV-1) set point among a cohort of African Americans (n= 515), and an intronic single …

Intracellular pathogens contribute to a significant proportion of infectious disease morbidity
and mortality worldwide. Increasing evidence points to a major role for host genetics in …

Elite controllers (EC) are HIV-1 infected patients control viral replication to a level of<
50copies/ml without antiretroviral therapy. These patients are also known as elite …

Genome-wide association studies can identify common differences that contribute to human
phenotypic diversity and disease. When genome-wide association studies are combined …

Genomic studies involving well‐defined multicenter cohorts of HIV‐1/AIDS covering multiple
populations have led to a greater understanding of the role of host determinants in viral …

Susceptibility to HIV-1 and the clinical course after infection show a substantial
heterogeneity between individuals. Part of this variability can be attributed to host genetic …

Delayed HIV-1 disease progression is associated with a single nucleotide polymorphism
upstream of the HLA-C gene that correlates with differential expression of the HLA-C Ag …