The mammalian cerebral cortex is responsible for higher cognitive functions such as
perception, consciousness, and acquiring and processing information. The neocortex is …

Apical radial glia comprise the pseudostratified neuroepithelium lining the embryonic lateral
ventricles and give rise to the extensive repertoire of pyramidal neuronal subtypes of the …

Outer radial glial (oRG) cells are a population of neural stem cells prevalent in the
developing human cortex that contribute to its cellular diversity and evolutionary expansion …

We previously established the contribution of de novo damaging sequence variants to
Tourette disorder (TD) through whole-exome sequencing of 511 trios. Here, we sequence …

Zinc-finger E-box binding homeobox 1 (Zeb1) is a key regulator of epithelial-mesenchymal
transition and cancer metastasis. Mutation of ZEB1 is associated with human diseases and …

Despite decades of study, elucidation of the underlying etiology of complex developmental
disorders such as autism spectrum disorder (ASD), schizophrenia (SCZ), intellectual …

Stroke is a main cause of death and disability worldwide. The ability of the brain to self-
repair in the acute and chronic phases after stroke is minimal; however, promising stem cell …

The cerebral cortex undergoes rapid folding in an “inside-outside” manner during embryonic
development resulting in the establishment of six discrete cortical layers. This unique …

The central nervous system (CNS) exhibits an extraordinary diversity of neurons, with the
right cell types and proportions at the appropriate sites. Thus, to produce brains with specific …

Neurons are the most extensive and polarized cells that display a unique single long axon
and multiple dendrites, which are compartments exhibiting structural and functional …