Activating transcription factor 4 (ATF4) is a stress-induced transcription factor that is
frequently upregulated in cancer cells. ATF4 controls the expression of a wide range of …

The unfolded protein response (UPR) is a stress response of the endoplasmic reticulum
(ER) to a disturbance in protein folding. The so-called ER stress sensors PERK, IRE1 and …

To achieve preferential effects against cancer cells but less damage to normal cells is one of
the main challenges of cancer research. In this review, we explore the roles and …

The unfolded protein response (UPR) is a conserved pathway that is stimulated when
endoplasmic reticulum (ER) proteostasis is disturbed or lost. Accumulating evidence …

The membrane-bound transcription factor ATF6α plays a cytoprotective role in the unfolded
protein response (UPR), required for cells to survive ER stress. Activation of ATF6α …

Cancer represents a serious global health problem, and its incidence and mortality are
rapidly growing worldwide. One of the main causes of the failure of an anticancer treatment …

The endoplasmic reticulum (ER) is a multifunctional organelle that constitutes the entry into
the secretory pathway. The ER contributes to the maintenance of cellular calcium …

Sirtuin family members are characterized by either mono-ADP-ribosyltransferase or
deacylase activity and are linked to various cancer-related biological pathways as regulators …

Abrogation of endoplasmic reticulum (ER) protein folding triggered by exogenous or
endogenous factors, stimulates a cellular stress response, termed ER stress. ER stress re …

Colorectal cancer (CRC) is a gastrointestinal malignancy originating from either the colon or
the rectum. A growing number of researches prove that the unfolded protein response (UPR) …