Aging, obesity, and inflammatory age-related diseases

D Frasca, BB Blomberg, R Paganelli - Frontiers in immunology, 2017 - frontiersin.org
The increase in the prevalence of obesity represents a worldwide phenomenon in all age
groups and is pathologically and genetically correlated with several metabolic and …

[HTML][HTML] Macrophages in obesity and non-alcoholic fatty liver disease: Crosstalk with metabolism

S Lefere, F Tacke - JHEP reports, 2019 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide, and
a major cause of liver cirrhosis and hepatocellular carcinoma. NAFLD is intimately linked …

Causal relationship between PCSK9 inhibitor and autoimmune diseases: a drug target Mendelian randomization study

W Xie, J Li, H Du, J Xia - Arthritis research & therapy, 2023 - Springer
Background In addition to decreasing the level of cholesterol, proprotein convertase subtilis
kexin 9 (PCSK9) inhibitor has pleiotropic effects, including immune regulation. However, the …

Adipokines: linking metabolic syndrome, the immune system, and arthritic diseases

V Francisco, C Ruiz-Fernández, J Pino, A Mera… - Biochemical …, 2019 - Elsevier
Metabolic syndrome (MetS) represents a cluster of metabolic and cardiovascular
complications, including obesity and visceral adiposity, insulin resistance, dyslipidemia …

NLRP3 at the interface of metabolism and inflammation

M Haneklaus, LAJ O'Neill - Immunological reviews, 2015 - Wiley Online Library
The discovery of the NLRP 3 (NLR family, pyrin domain containing 3) inflammasome
provided an important molecular mechanism in the induction of the central pro‐inflammatory …

Cardiovascular effects of approved drugs for rheumatoid arthritis

F Atzeni, J Rodríguez-Carrio, CD Popa… - Nature Reviews …, 2021 - nature.com
The risk of cardiovascular disease is increased in patients with rheumatoid arthritis
compared with the general population owing to the influence of traditional and non …

Changes in body composition and metabolic profile during interleukin 6 inhibition in rheumatoid arthritis

A Tournadre, B Pereira, F Dutheil… - Journal of cachexia …, 2017 - Wiley Online Library
Background Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by
increased mortality associated with cardiometabolic disorders including dyslipidaemia …

Serum metabolomic and lipidomic profiling identifies diagnostic biomarkers for seropositive and seronegative rheumatoid arthritis patients

H Luan, W Gu, H Li, Z Wang, L Lu, M Ke, J Lu… - Journal of translational …, 2021 - Springer
Background Diagnosing seronegative rheumatoid arthritis (RA) can be challenging due to
complex diagnostic criteria. We sought to discover diagnostic biomarkers for seronegative …

[HTML][HTML] Cardiovascular risk assessment in patients with rheumatoid arthritis: The relevance of clinical, genetic and serological markers

R López-Mejías, S Castañeda… - Autoimmunity …, 2016 - Elsevier
Cardiovascular disease (CV) is the most common cause of premature mortality in patients
with rheumatoid arthritis (RA). This is the result of an accelerated atherosclerotic process …

Resolvin T4 enhances macrophage cholesterol efflux to reduce vascular disease

ME Walker, R De Matteis, M Perretti, J Dalli - Nature Communications, 2024 - nature.com
While cardiovascular disease (CVD) is one of the major co-morbidities in patients with
rheumatoid arthritis (RA), the mechanism (s) that contribute to CVD in patients with RA …