Luminescence imaging is a powerful and versatile technique for investigating cell
physiology and pathology in living systems, making significant contributions to life science …

Lactate shuttled from the blood circulation, astrocytes, oligodendrocytes or even activated
microglia (resident macrophages) to neurons has been hypothesized to represent a major …

During transient brain activation cerebral blood flow (CBF) increases substantially more than
cerebral metabolic rate of oxygen consumption (CMRO2) resulting in blood …

Isoflurane is one of the most widely used anesthetic agents in rodent imaging studies.
However, the impact of isoflurane on brain metabolism has not been fully characterized to …

Background and objective: Oxygen is carried to the brain by blood flow through generations
of vessels across a wide range of length scales. This multi-scale nature of blood flow and …

Recent progresses in intravital imaging have enabled highly-resolved measurements of
periarteriolar oxygen gradients (POGs) within the brain parenchyma. POGs are increasingly …

Blood-oxygenation-level-dependent functional magnetic resonance imaging (BOLD fMRI) of
cortical layers relies on the hemodynamic response and is biased toward large veins on the …

Background Neuroinflammation, impaired metabolism, and hypoperfusion are fundamental
pathological hallmarks of early Alzheimer's disease (AD). Numerous studies have asserted …

Two-photon phosphorescence lifetime microscopy has been a key tool for studying cerebral
oxygenation in mice. However, the accuracy of the partial pressure of oxygen (pO_2) …

Over the last decade, increased efforts have been made to standardize the curation, storage,
and retrieval of scholarly data (Data Citation Synthesis Group, 2014; Nosek et al., 2015; …