From selenium to selenoproteins: synthesis, identity, and their role in human health
The requirement of the trace element selenium for life and its beneficial role in human health
has been known for several decades. This is attributed to low molecular weight selenium …
has been known for several decades. This is attributed to low molecular weight selenium …
Function and biological roles of the Dickkopf family of Wnt modulators
C Niehrs - Oncogene, 2006 - nature.com
Dickkopf (Dkk) genes comprise an evolutionary conserved small gene family of four
members (Dkk1-4) and a unique Dkk3-related gene, Dkkl1 (soggy). They encode secreted …
members (Dkk1-4) and a unique Dkk3-related gene, Dkkl1 (soggy). They encode secreted …
Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer
D Lodygin, V Tarasov, A Epanchintsev, C Berking… - Cell cycle, 2008 - Taylor & Francis
Recently, we and others identified the microRNA miR-34a as a target of the tumor
suppressor gene product p53. Ectopic miR-34a induces a G1 cell cycle arrest, senescence …
suppressor gene product p53. Ectopic miR-34a induces a G1 cell cycle arrest, senescence …
Wnt/β-catenin signalling in prostate cancer
RM Kypta, J Waxman - Nature Reviews Urology, 2012 - nature.com
The Wnts are secreted cysteine-rich glycoproteins that have important roles in the
developing embryo as well as in tissue homeostasis in adults. Dysregulation of Wnt …
developing embryo as well as in tissue homeostasis in adults. Dysregulation of Wnt …
Glutathione peroxidases in different stages of carcinogenesis
R Brigelius-Flohe, A Kipp - Biochimica et Biophysica Acta (BBA)-General …, 2009 - Elsevier
Cancer cells produce high amounts of reactive oxygen species (ROS) and evade apoptosis.
Hydroperoxides support proliferation, invasion, migration and angiogenesis, but at higher …
Hydroperoxides support proliferation, invasion, migration and angiogenesis, but at higher …
DNA microarrays: a powerful genomic tool for biomedical and clinical research
V Trevino, F Falciani, HA Barrera-Saldaña - Molecular medicine, 2007 - Springer
Among the many benefits of the Human Genome Project are new and powerful tools such as
the genome-wide hybridization devices referred to as microarrays. Initially designed to …
the genome-wide hybridization devices referred to as microarrays. Initially designed to …
Epigenetics in prostate cancer: biologic and clinical relevance
C Jerónimo, PJ Bastian, A Bjartell, GM Carbone… - European urology, 2011 - Elsevier
CONTEXT: Prostate cancer (PCa) is one of the most common human malignancies and
arises through genetic and epigenetic alterations. Epigenetic modifications include DNA …
arises through genetic and epigenetic alterations. Epigenetic modifications include DNA …
Genome-wide methylation analysis identifies epigenetically inactivated candidate tumour suppressor genes in renal cell carcinoma
The detection of promoter region hypermethylation and transcriptional silencing has
facilitated the identification of candidate renal cell carcinoma (RCC) tumour suppressor …
facilitated the identification of candidate renal cell carcinoma (RCC) tumour suppressor …
Insights into the role of GPX3, a highly efficient plasma antioxidant, in cancer
S Nirgude, B Choudhary - Biochemical pharmacology, 2021 - Elsevier
Glutathione peroxidases are well known antioxidant enzymes. They catalyze the reduction
of hydrogen peroxide or organic hydroperoxides using glutathione. Among the reported 8 …
of hydrogen peroxide or organic hydroperoxides using glutathione. Among the reported 8 …
Secreted frizzled-related protein 1 loss contributes to tumor phenotype of clear cell renal cell carcinoma
ML Gumz, H Zou, PA Kreinest, AC Childs… - Clinical cancer …, 2007 - AACR
Purpose: Incidence and mortality rates for renal cell carcinoma (RCC) have been rising for
decades. Unfortunately, the molecular events that support RCC carcinogenesis remain …
decades. Unfortunately, the molecular events that support RCC carcinogenesis remain …