It is hypothesized that glucokinase (GCK) is the glucose sensor not only for regulation of
insulin release by pancreatic β-cells, but also for the rest of the cells that contribute to …

Non-alcoholic fatty liver disease (NAFLD) is a clinicopathological change characterized by
the accumulation of triglycerides in hepatocytes and has frequently been associated with …

Glucokinase is a monomeric enzyme that displays a low affinity for glucose and a sigmoidal
saturation curve for its substrate, two properties that are important for its playing the role of a …

Increasing consumption of sugars is one of the contributing factors to the obesity epidemic.
Both cane sugar and high-fructose corn syrup contain glucose and fructose. Fructose, in …

Conversion of glucose into glycogen is a major pathway that contributes to the removal of
glucose from the portal vein by the liver in the postprandial state. It is regulated in part by the …

We investigated the association of glycemia and 43 genetic risk variants for
hyperglycemia/type 2 diabetes with amino acid levels in the population-based Metabolic …

Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely
with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to …

Type 2 diabetes mellitus is a metabolic disorder with complicated pathogenesis, and mono-
target therapy often fails to effectively manage the levels of blood glucose. In recent years …

Glucose not only serves as a nutrient but also exerts many hormone-like regulatory effects in
a wide variety of eukaryotic cell types. Recently, interest in identifying general mechanisms …

Obesity-associated insulin resistance (IR) is a major risk factor for developing type 2
diabetes and an array of other metabolic disorders. In particular, hepatic IR contributes to the …