Diseases caused by tropical parasites affect hundreds of millions of people worldwide but
have been largely neglected for drug development because they affect poor people in poor …

The thymine− uracil exchange constitutes one of the major chemical differences between
DNA and RNA. Although these two bases form the same Watson− Crick base pairs with …

Malaria is a leading cause of morbidity and mortality in the tropics. Chemotherapeutic and
vector control strategies have been applied for more than a century but have not been …

Compared to the previous year, there has been an increase of nearly 2 million malaria
cases in 2021. The emergence of drug-resistant strains of Plasmodium falciparum, the most …

Deoxyuridine triphosphatase (dUTPase) has emerged as a potential target for drug
development as a 5-fluorouracil-based combination chemotherapy. We describe the design …

The efficacy of most marketed antimalarial drugs has been compromised by evolution of
parasite resistance, underscoring an urgent need to find new drugs with new mechanisms of …

A key step in the development of new pharmaceutical drugs is the identification of the
molecular target and distinguishing this from all other gene products that respond indirectly …

ABSTRACT E165R, a highly specific dUTP nucleotidohydrolase (dUTPase) encoded by the
African swine fever virus (ASFV) genome, is required for productive replication of ASFV in …

Malaria is one of the life‐threatening diseases in the world. The spread of resistance to
antimalarial drugs is a major challenge, and resistance to artemisinin has been reported in …

Thymidine biosynthesis is essential in all cells. Inhibitors of the enzymes involved in this
pathway (eg methotrexate) are thus frequently used as cytostatics. Due to its pivotal role in …