[HTML][HTML] Optimizing intracellular antibodies (intrabodies/nanobodies) to treat neurodegenerative disorders

A Messer, DC Butler - Neurobiology of disease, 2020 - Elsevier
Intrabodies (both single-chain Fv and single-domain VH, VHH, and VL nanobodies) offer
unique solutions to some of the challenges of delivery and target engagement posed by …

Hepatitis C virus leaves an epigenetic signature post cure of infection by direct-acting antivirals

S Perez, A Kaspi, T Domovitz, A Davidovich… - PLoS …, 2019 - journals.plos.org
The increasing worldwide prevalence of Hepatocellular carcinoma (HCC), characterized by
resistance to conventional chemotherapy, poor prognosis and eventually mortality, place it …

Applying antibodies inside cells: principles and recent advances in neurobiology, virology and oncology

C Zhang, RM Ötjengerdes, J Roewe, R Mejias… - BioDrugs, 2020 - Springer
To interfere with cell function, many scientists rely on methods that target DNA or RNA due to
the ease with which they can be applied. Proteins are usually the final executors of function …

HCV infection increases the expression of ACE2 receptor, leading to enhanced entry of both HCV and SARS-CoV-2 into hepatocytes and a coinfection state

T Domovitz, S Ayoub, M Werbner, J Alter… - Microbiology …, 2022 - Am Soc Microbiol
Recent studies suggest the enhancement of liver injury in COVID-19 patients infected with
Hepatitis C virus (HCV). Hepatocytes express low levels of angiotensin-converting enzyme 2 …

Hepatitis C virus enhances the invasiveness of hepatocellular carcinoma via EGFR-mediated invadopodia formation and activation

L Ninio, A Nissani, T Meirson, T Domovitz, A Genna… - Cells, 2019 - mdpi.com
Hepatocellular carcinoma (HCC) represents the fifth most common cancer worldwide and
the third cause of cancer-related mortality. Hepatitis C virus (HCV) is the leading cause of …

Engineering antibodies and proteins for molecular in vivo imaging

T Romer, H Leonhardt, U Rothbauer - Current opinion in biotechnology, 2011 - Elsevier
The rapid and ongoing discovery of new disease related biomarkers leads to a dramatic
paradigm change in human healthcare and constitutes the basis for a truly personalized …

Removal of hepatitis C virus-infected cells by a zymogenized bacterial toxin

A Shapira, S Shapira, M Gal-Tanamy, R Zemel… - PloS one, 2012 - journals.plos.org
Hepatitis C virus (HCV) infection is a major cause of chronic liver disease and has become a
global health threat. No HCV vaccine is currently available and treatment with antiviral …

The role of microRNAs in the management of liver cancer

KK Banaudha, M Verma - Cancer Epigenetics: Methods and Protocols, 2012 - Springer
Four major components of epigenetic regulation are promoter methylation, histone
modification, chromatin conformation changes, and altered expression of noncoding RNAs …

precision medicine approaches for genetic cardiomyopathy: targeting phospholamban R14del

FE Deiman, N Bomer, P van der Meer… - Current heart failure …, 2022 - Springer
Abstract Purpose of Review Heart failure is a syndrome with poor prognosis and no curative
options for the majority of patients. The standard one-size-fits-all-treatment approach …

Dysregulation of the cohesin subunit RAD21 by Hepatitis C virus mediates host–virus interactions

S Perez, M Gevor, A Davidovich, A Kaspi… - Nucleic Acids …, 2019 - academic.oup.com
Hepatitis C virus (HCV) infection is the leading cause of chronic hepatitis, which often results
in liver fibrosis, cirrhosis and hepatocellular carcinoma (HCC). HCV possesses an RNA …