Programmed and self-organized flow of information during morphogenesis
C Collinet, T Lecuit - Nature Reviews Molecular Cell Biology, 2021 - nature.com
How the shape of embryos and organs emerges during development is a fundamental
question that has fascinated scientists for centuries. Tissue dynamics arise from a small set …
question that has fascinated scientists for centuries. Tissue dynamics arise from a small set …
Patterning of the cell cortex by Rho GTPases
Abstract The Rho GTPases—RHOA, RAC1 and CDC42—are small GTP binding proteins
that regulate basic biological processes such as cell locomotion, cell division and …
that regulate basic biological processes such as cell locomotion, cell division and …
Adherens junctions as molecular regulators of emergent tissue mechanics
Tissue and organ development during embryogenesis relies on the collective and
coordinated action of many cells. Recent studies have revealed that tissue material …
coordinated action of many cells. Recent studies have revealed that tissue material …
Mechanochemical principles of spatial and temporal patterns in cells and tissues
Patterns are ubiquitous in living systems and underlie the dynamic organization of cells,
tissues, and embryos. Mathematical frameworks have been devised to account for the self …
tissues, and embryos. Mathematical frameworks have been devised to account for the self …
From actin waves to mechanism and back: how theory aids biological understanding
Actin dynamics in cell motility, division, and phagocytosis is regulated by complex factors
with multiple feedback loops, often leading to emergent dynamic patterns in the form of …
with multiple feedback loops, often leading to emergent dynamic patterns in the form of …
Genetic induction and mechanochemical propagation of a morphogenetic wave
Tissue morphogenesis arises from coordinated changes in cell shape driven by actomyosin
contractions. Patterns of gene expression regionalize cell behaviours by controlling …
contractions. Patterns of gene expression regionalize cell behaviours by controlling …
The actin cytoskeleton as an active adaptive material
S Banerjee, ML Gardel… - Annual review of …, 2020 - annualreviews.org
Actin is the main protein used by biological cells to adapt their structure and mechanics to
their needs. Cellular adaptation is made possible by molecular processes that strongly …
their needs. Cellular adaptation is made possible by molecular processes that strongly …
Generation of stress fibers through myosin-driven reorganization of the actin cortex
JI Lehtimäki, EK Rajakylä, S Tojkander, P Lappalainen - Elife, 2021 - elifesciences.org
Contractile actomyosin bundles, stress fibers, govern key cellular processes including
migration, adhesion, and mechanosensing. Stress fibers are thus critical for developmental …
migration, adhesion, and mechanosensing. Stress fibers are thus critical for developmental …
Mechanics of the cellular actin cortex: From signalling to shape change
The actin cortex is a thin layer of actin, myosin and actin-binding proteins that underlies the
membrane of most animal cells. It is highly dynamic and can undergo remodelling on …
membrane of most animal cells. It is highly dynamic and can undergo remodelling on …
A versatile cortical pattern-forming circuit based on Rho, F-actin, Ect2, and RGA-3/4
Many cells can generate complementary traveling waves of actin filaments (F-actin) and
cytoskeletal regulators. This phenomenon, termed cortical excitability, results from coupled …
cytoskeletal regulators. This phenomenon, termed cortical excitability, results from coupled …