The biological applications of DNA nanomaterials: current challenges and future directions

W Ma, Y Zhan, Y Zhang, C Mao, X Xie… - Signal transduction and …, 2021 - nature.com
DNA, a genetic material, has been employed in different scientific directions for various
biological applications as driven by DNA nanotechnology in the past decades, including …

Polymeric delivery of therapeutic nucleic acids

R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Decellularized tissues for wound healing: towards closing the gap between scaffold design and effective extracellular matrix remodeling

VA Solarte David, VR Güiza-Argüello… - … in Bioengineering and …, 2022 - frontiersin.org
The absence or damage of a tissue is the main cause of most acute or chronic diseases and
are one of the appealing challenges that novel therapeutic alternatives have, in order to …

Regulation and function of SOX9 during cartilage development and regeneration

H Song, KH Park - Seminars in cancer biology, 2020 - Elsevier
Chondrogenesis is a highly coordinated event in embryo development, adult homeostasis,
and repair of the vertebrate cartilage. Fate decisions and differentiation of chondrocytes …

A critical review on the synthesis of natural sodium alginate based composite materials: An innovative biological polymer for biomedical delivery applications

A Ahmad, NM Mubarak, FT Jannat, T Ashfaq, C Santulli… - Processes, 2021 - mdpi.com
Sodium alginate (Na-Alg) is water-soluble, neutral, and linear polysaccharide. It is the
derivative of alginic acid which comprises 1, 4-β-d-mannuronic (M) and α-l-guluronic (G) …

Toxicity of cationic lipids and cationic polymers in gene delivery

H Lv, S Zhang, B Wang, S Cui, J Yan - Journal of controlled release, 2006 - Elsevier
Gene therapy, as a promising therapeutics to treat genetic or acquired diseases, has
achieved exciting development in the past two decades. Appropriate gene vectors can be …

Instructive microenvironments in skin wound healing: Biomaterials as signal releasing platforms

O Castano, S Pérez-Amodio… - Advanced drug delivery …, 2018 - Elsevier
Skin wound healing aims to repair and restore tissue through a multistage process that
involves different cells and signalling molecules that regulate the cellular response and the …

Biodegradable polymers for gene delivery

TJ Thomas, HA Tajmir-Riahi, CKS Pillai - Molecules, 2019 - mdpi.com
The cellular transport process of DNA is hampered by cell membrane barriers, and hence, a
delivery vehicle is essential for realizing the potential benefits of gene therapy to combat a …

Nanomedicine for drug delivery and imaging: a promising avenue for cancer therapy and diagnosis using targeted functional nanoparticles

Y Liu, H Miyoshi, M Nakamura - International journal of cancer, 2007 - Wiley Online Library
The diagnosis and treatment of cancer or tumor at the cellular level will be greatly improved
with the development of techniques that enable the delivery of analyte probes and …

Polymers for gene delivery across length scales

D Putnam - Nature materials, 2006 - nature.com
A number of human diseases stem from defective genes. One approach to treating such
diseases is to replace, or override, the defective genes with normal genes, an approach …