Uncovering the cis-regulatory code that governs when and how much each gene is
transcribed in a given genome and cellular state remains a central goal of biology. Here, we …

The Mediator complex, which in humans is 1.4 MDa in size and includes 26 subunits,
controls many aspects of RNA polymerase II (Pol II) function. Apart from its size, a defining …

Cancer is a disease of uncontrollably reproducing cells. It is governed by biochemical
pathways that have escaped the regulatory bounds of normal homeostatic balance. This …

Abstract The RNA polymerase II (Pol II) pre-initiation complex (PIC) is a critical node in
eukaryotic transcription regulation, and its formation is the major rate-limiting step in …

Precise patterns of gene expression in metazoans are controlled by three classes of
regulatory elements: promoters, enhancers and boundary elements. During differentiation …

The spatiotemporal control of gene expression is dependent on the activity of cis-acting
regulatory sequences, called enhancers, which regulate target genes over variable genomic …

Few transcription factors have been examined for their direct roles in physically connecting
enhancers and promoters. Here acute degradation of Yin Yang 1 (YY1) in erythroid cells …

Eukaryotic gene regulation and pre-mRNA transcription depend on the carboxy-terminal
domain (CTD) of RNA polymerase (Pol) II. Due to its highly repetitive, intrinsically disordered …

All multicellular organisms rely on differential gene transcription regulated by genomic
enhancers, which function through cofactors that are recruited by transcription factors …

INTRODUCTION RNA polymerase II (Pol II)–mediated transcription initiation requires
assembly of a preinitiation complex (PIC), during which the 14-subunit transcription factor IID …