Osteoarthritis comprises several joint disorders characterized by articular cartilage
degeneration and persistent pain, causing disability and economic burden. The incidence of …

Osteocytes are an ancient cell, appearing in fossilized skeletal remains of early fish and
dinosaurs. Despite its relative high abundance, even in the context of nonskeletal cells, the …

The skeleton is a dynamic organ that is constantly remodeled. Proteins secreted from bone
cells, namely osteoblasts, osteocytes, and osteoclasts exert regulation on …

Osteocytes play a critical role in maintaining bone homeostasis and in regulating skeletal
response to hormones and mechanical loading. Substantial evidence have demonstrated …

The knowledge of bone biology has largely changed in the last few decades. Osteocytes are
multifunctional bone cells that are surrounded by mineralized bone matrix and for decades it …

Sclerostin, a SOST protein secreted by osteocytes, negatively regulates formation of
mineralized bone matrix and bone mass. We report the results of a randomized, double …

Highlights•Osteocytes regulate bone formation through a number of interacting signalling
pathways.•Osteocytes regulate bone resorption through controlling osteoclast activity and …

The temporomandibular joint (TMJ) is a specialized synovial joint that is crucial for the
movement and function of the jaw. TMJ osteoarthritis (TMJ OA) is the result of disc …

Periprosthetic joint infection (PJI) is a potentially devastating complication of orthopedic joint
replacement surgery. PJI with associated osteomyelitis is particularly problematic and …

Poor bone quality contributes to bone fragility in diabetes, aging, and osteogenesis
imperfecta. However, the mechanisms controlling bone quality are not well understood …