Cell types rich in mitochondria, including neurons, display a high energy demand and a
need for calcium buffering. The importance of mitochondria for proper neuronal function is …

The Drosophila neuromuscular junction (NMJ) has recently provided new insights into the
roles of various proteins in neurodegenerative diseases including Amyotrophic Lateral …

Hsp90 is an essential chaperone that guards proteome integrity and amounts to 2% of
cellular protein. We now find that Hsp90 also has the ability to directly interact with and …

Synapses are often far from their cell bodies and must largely independently cope with
dysfunctional proteins resulting from synaptic activity and stress. To identify membrane …

Nervous system function relies on the polarized architecture of neurons, established by
directional transport of pre-and postsynaptic cargoes. While delivery of postsynaptic …

Synapse assembly requires trans-synaptic signals between the pre-and postsynapse, but
our understanding of the essential organizational molecules involved in this process …

Neuronal activity causes use-dependent decline in protein function. However, it is unclear
how this is coupled to local quality control mechanisms. We show in Drosophila that the …

Exchange of proteins at sorting endosomes is not only critical to numerous signaling
pathways but also to receptor-mediated signaling and to pathogen entry into cells; however …

Amyotrophic Lateral Sclerosis (ALS), is a fatal neurodegenerative disorder, with TDP-43
inclusions as a major pathological hallmark. Using a Drosophila model of TDP-43 …

Amyotrophic lateral sclerosis (ALS) is a synaptopathy accompanied by the presence of
cytoplasmic aggregates containing TDP-43, an RNA-binding protein linked to∼ 97% of ALS …