microRNAs in action: biogenesis, function and regulation
Ever since microRNAs (miRNAs) were first recognized as an extensive gene family> 20
years ago, a broad community of researchers was drawn to investigate the universe of small …
years ago, a broad community of researchers was drawn to investigate the universe of small …
microRNA strand selection: Unwinding the rules
Abstract microRNAs (miRNAs) play a central role in the regulation of gene expression by
targeting specific mRNAs for degradation or translational repression. Each miRNA is post …
targeting specific mRNAs for degradation or translational repression. Each miRNA is post …
Regulatory mechanisms of microRNA expression
LF Gulyaeva, NE Kushlinskiy - Journal of translational medicine, 2016 - Springer
MicroRNAs (miRs, miRNAs) are small molecules of 18–22 nucleotides that serve as
important regulators of gene expression at the post-transcriptional level. One of the …
important regulators of gene expression at the post-transcriptional level. One of the …
Role of microRNAs in obesity and obesity-related diseases
G Iacomino, A Siani - Genes & nutrition, 2017 - Springer
In recent years, the link between regulatory microRNAs (miRNAs) and diseases has been
the object of intensive research. miRNAs have emerged as key mediators of metabolic …
the object of intensive research. miRNAs have emerged as key mediators of metabolic …
The roles of microRNAs in regulation of mammalian spermatogenesis
X Chen, X Li, J Guo, P Zhang, W Zeng - Journal of Animal Science and …, 2017 - Springer
Mammalian spermatogenesis contains three continuous and organized processes, by which
spermatogonia undergo mitosis and differentiate to spermatocytes, follow on meiosis to form …
spermatogonia undergo mitosis and differentiate to spermatocytes, follow on meiosis to form …
MicroRNA clustering assists processing of suboptimal microRNA hairpins through the action of the ERH protein
Microprocessor initiates the processing of microRNAs (miRNAs) from the hairpin regions of
primary transcripts (pri-miRNAs). Pri-miRNAs often contain multiple miRNA hairpins, and …
primary transcripts (pri-miRNAs). Pri-miRNAs often contain multiple miRNA hairpins, and …
Regulation of primary micro RNA processing
A Creugny, A Fender, S Pfeffer - FEBS letters, 2018 - Wiley Online Library
Micro RNA s (mi RNA s) are evolutionarily conserved small regulatory RNA s that participate
in the adjustment of many, if not all, fundamental biological processes. Molecular …
in the adjustment of many, if not all, fundamental biological processes. Molecular …
Guidelines for the optimal design of miRNA-based shRNAs
X Bofill-De Ros, S Gu - Methods, 2016 - Elsevier
RNA interference (RNAi) is an extremely useful tool for inhibiting gene expression. It can be
triggered by transfected synthetic small interfering RNA (siRNA) or by expressed small …
triggered by transfected synthetic small interfering RNA (siRNA) or by expressed small …
Expression and role of microRNAs from the miR-200 family in the tumor formation and metastatic propensity of pancreatic cancer
ZV Diaz-Riascos, MM Ginesta, J Fabregat… - … Therapy-Nucleic Acids, 2019 - cell.com
MicroRNAs from the miR-200 family are commonly associated with the inhibition of the
metastatic potential of cancer cells, following inhibition of ZEB transcription factors …
metastatic potential of cancer cells, following inhibition of ZEB transcription factors …
Dynamic Protein-RNA recognition in primary MicroRNA processing
VM Ruiz-Arroyo, Y Nam - Current opinion in structural biology, 2022 - Elsevier
MicroRNAs are prevalent regulators of gene expression, controlling most of the proteome in
multicellular organisms. To generate the functional small RNAs, precise processing steps …
multicellular organisms. To generate the functional small RNAs, precise processing steps …